{"id":"W4391596701","doi":"10.1038/d41586-024-00305-3","title":"Turbocharged CAR-T cells melt tumours in mice — using a trick from cancer cells","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"World Federation of Science Journalists","funders":"","keywords":"Immune system; Cancer cell; Potency; Cancer; Cancer research; Mutation; Biology; Chemistry; Molecular biology; Immunology; Genetics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000437259,0.0008299802,0.0006743014,0.0007851282,0.0004147427,0.0008099893,0.0007465072,0.001536957,0.003014124],"category_scores_gemma":[0.0003393566,0.0006029845,0.001019354,0.0002558893,0.000912652,0.0009607532,0.0006123174,0.003996579,0.001264237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003973991,"about_ca_system_score_gemma":0.0004483763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009308317,"about_ca_topic_score_gemma":0.0009233764,"domain_scores_codex":[0.9993922,0.00004889464,0.00003570715,0.0001815148,0.0001721145,0.0001695265],"domain_scores_gemma":[0.9996182,0.0001026318,0.00009725455,0.00007165652,0.00002875596,0.00008158707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004714974,0.00006477354,0.0001415829,0.00007848048,0.00002993158,0.00009692691,0.00005046589,0.000399133,0.9927225,0.001404685,0.0004192897,0.004120796],"study_design_scores_gemma":[0.00006959,0.0005776594,0.0004382519,0.0000115232,0.00003826054,0.0003492877,0.00001947072,0.001613354,0.9915981,0.0003669887,0.004904344,0.00001304828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240224,0.004838804,0.05183741,0.001979146,0.001062499,0.000398092,0.001361956,0.00313521,0.01136453],"genre_scores_gemma":[0.9575816,0.001554218,0.0209213,0.0005319149,0.0001691661,0.0002075167,0.000609811,0.0006492006,0.0177753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003014124,"threshold_uncertainty_score":0.0100832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162880177524954,"score_gpt":0.3437808577306855,"score_spread":0.3221520559554359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}