{"id":"W4391596910","doi":"10.1021/acscentsci.3c01598","title":"Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i>","year":2024,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; H2020 European Research Council; National Natural Science Foundation of China; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Streptococcus gordonii; Isothermal titration calorimetry; Glycan; Glycobiology; Chemistry; Bacterial adhesin; Glycoprotein; Plasma protein binding; Biochemistry; Computational biology; Biology; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904725,0.0002361638,0.0002448357,0.000155382,0.0003000101,0.0001142008,0.000247355,0.0001040022,0.00004852301],"category_scores_gemma":[0.0001066167,0.0001551107,0.0001536099,0.00162708,0.0008202161,0.000317387,0.00008872242,0.0002651653,0.00008867687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622793,"about_ca_system_score_gemma":0.0003860207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002988325,"about_ca_topic_score_gemma":0.00005207718,"domain_scores_codex":[0.9978658,0.00005318511,0.0003595581,0.0005930295,0.0005701499,0.0005582927],"domain_scores_gemma":[0.9989408,0.0001074943,0.00008628728,0.0004240962,0.0001616522,0.0002796476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003132426,0.000278121,0.003576295,0.00005275221,0.0000873914,0.00007650196,0.0005951859,0.00001984937,0.9388548,0.0004825826,0.001235196,0.05471006],"study_design_scores_gemma":[0.0007802485,0.0004900366,0.008797791,0.0002658447,0.0002222231,0.00004400912,0.0001331695,0.0007333736,0.9810864,0.0020039,0.0052093,0.0002336982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932428,0.001050771,0.0004802897,0.0006612173,0.0006787402,0.0009812646,0.00002207652,0.0001264355,0.002756405],"genre_scores_gemma":[0.9988499,0.0002808938,0.00007441309,0.0004292775,0.00008697072,0.0001059716,0.00005699744,0.00002088053,0.00009471142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05447637,"threshold_uncertainty_score":0.6325229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209933212807953,"score_gpt":0.2633096906466654,"score_spread":0.2512103585185859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}