{"id":"W4391596910","doi":"10.1021/acscentsci.3c01598","title":"Molecular Insights into O-Linked Sialoglycans Recognition by the Siglec-Like SLBR-N (SLBR<sub>UB10712</sub>) of <i>Streptococcus gordonii</i>","year":2024,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; H2020 European Research Council; National Natural Science Foundation of China; National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Streptococcus gordonii; Isothermal titration calorimetry; Glycan; Glycobiology; Chemistry; Bacterial adhesin; Glycoprotein; Plasma protein binding; Biochemistry; Computational biology; Biology; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008512494,0.0002510565,0.0001714002,0.00009896569,0.0001024725,0.0001541426,0.0002421753,0.0003056964,0.0006382841],"category_scores_gemma":[0.00007692726,0.00008204386,0.0001950989,0.00008363478,0.0001355744,0.0001920447,0.00009945167,0.0002702804,0.0001336802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667079,"about_ca_system_score_gemma":0.0001876376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735114,"about_ca_topic_score_gemma":0.002375999,"domain_scores_codex":[0.9999684,0.000003732147,0.000001663129,0.000006271636,0.00001291255,0.00000706273],"domain_scores_gemma":[0.9999793,0.000004451925,0.00000466447,0.000001446919,0.000003985097,0.000006274569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001022973,0.00003623184,0.001481067,0.00006945837,0.0000111129,0.0001082336,0.00002736799,0.001993166,0.9936009,0.0003022955,0.0001382423,0.002129558],"study_design_scores_gemma":[0.00002798914,0.0004549053,0.03067119,0.00001979133,0.00005231389,0.0003704332,0.0003022559,0.1753699,0.7876506,0.0007463688,0.004295499,0.00003873974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945486,0.000630505,0.003390928,0.0001705217,0.00001275163,0.000008526686,0.0002245021,0.00008470684,0.0009287586],"genre_scores_gemma":[0.991383,0.0006424375,0.006645466,0.000107941,0.000005291115,0.000009031374,0.0004528861,0.00001474886,0.0007390885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001735114,"threshold_uncertainty_score":0.003449976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01209933212807953,"score_gpt":0.2633096906466654,"score_spread":0.2512103585185859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}