{"id":"W4391598248","doi":"10.1001/jamapsychiatry.2023.5483","title":"Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity","year":2024,"lang":"en","type":"review","venue":"JAMA Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Université de Montréal","funders":"University of Colorado School of Medicine, Anschutz Medical Campus; National Center for Complementary and Alternative Medicine; National Center for Complementary and Integrative Health; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Faculty of Medicine and Health, University of Sydney; National Cancer Institute; Melbourne School of Psychological Sciences; Department of Psychiatry, Faculty of Medicine, University of British Columbia; Laureate Institute for Brain Research, University of Tulsa; Perelman School of Medicine, University of Pennsylvania; Sydney Medical School; University of California, San Diego; National Institutes of Health; McGovern Institute for Brain Research, Massachusetts Institute of Technology; Wake Forest School of Medicine; Université de Montréal; National Institute of Diabetes and Digestive and Kidney Diseases; Universitätsspital Zürich; Universiteit van Amsterdam; McGill University; Deutsche Forschungsgemeinschaft; McLean Hospital; Amsterdam Neuroscience; Linköpings Universitet; National Institute of Mental Health; University of St Andrews; Brown University; Virginia Commonwealth University; Amsterdam University Medical Centers; University of California, Los Angeles; University of Minnesota; Tehran University of Medical Sciences and Health Services; University of South Carolina; Universität Zürich; National Institute on Drug Abuse; University of Pennsylvania; Szegedi Tudományegyetem; BrainsWay; Massachusetts Institute of Technology; Pennsylvania State University","keywords":"Biomarker; Medicine; Drug development; MEDLINE; Clinical study design; Imaging biomarker; Addiction; Clinical trial; Psychology; Magnetic resonance imaging; Psychiatry; Internal medicine; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003800495,0.0004737502,0.001083081,0.0005218814,0.00004320079,0.0001238501,0.0004502836,0.0003184335,0.00002213853],"category_scores_gemma":[0.0001196188,0.0004306573,0.00039622,0.0005670359,0.0001501496,0.0002063421,0.0001391121,0.0006535142,0.00006412029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007784735,"about_ca_system_score_gemma":0.0004255988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001615789,"about_ca_topic_score_gemma":0.00001478275,"domain_scores_codex":[0.9970789,0.0002415796,0.0008109714,0.001076725,0.0003688357,0.0004230065],"domain_scores_gemma":[0.9988024,0.0002637071,0.0003343804,0.0004687622,0.00001989643,0.0001108151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003817793,0.0002096693,0.00008220357,0.01207365,0.00002263722,0.00003257334,0.000124519,1.122056e-7,0.0007053947,0.0001823448,0.002204082,0.9843246],"study_design_scores_gemma":[0.0006113161,0.00004105614,0.000582415,0.008988521,0.0004055956,0.0001041291,0.000009712871,0.000005752284,0.0006458525,0.0002520775,0.9877564,0.0005971682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07579028,0.9150836,0.00005228183,0.0005862997,0.004667683,0.003298888,0.0002836827,0.0001087742,0.0001285265],"genre_scores_gemma":[0.002275784,0.9909565,0.005012169,0.0002581181,0.0001595303,0.0006617082,0.00001548045,0.0001827895,0.0004779011],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9855523,"threshold_uncertainty_score":0.9998145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688429884089718,"score_gpt":0.3393752129726443,"score_spread":0.2924909141317471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}