{"id":"W4391598248","doi":"10.1001/jamapsychiatry.2023.5483","title":"Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity","year":2024,"lang":"en","type":"review","venue":"JAMA Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Université de Montréal","funders":"University of Colorado School of Medicine, Anschutz Medical Campus; National Center for Complementary and Alternative Medicine; National Center for Complementary and Integrative Health; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Faculty of Medicine and Health, University of Sydney; National Cancer Institute; Melbourne School of Psychological Sciences; Department of Psychiatry, Faculty of Medicine, University of British Columbia; Laureate Institute for Brain Research, University of Tulsa; Perelman School of Medicine, University of Pennsylvania; Sydney Medical School; University of California, San Diego; National Institutes of Health; McGovern Institute for Brain Research, Massachusetts Institute of Technology; Wake Forest School of Medicine; Université de Montréal; National Institute of Diabetes and Digestive and Kidney Diseases; Universitätsspital Zürich; Universiteit van Amsterdam; McGill University; Deutsche Forschungsgemeinschaft; McLean Hospital; Amsterdam Neuroscience; Linköpings Universitet; National Institute of Mental Health; University of St Andrews; Brown University; Virginia Commonwealth University; Amsterdam University Medical Centers; University of California, Los Angeles; University of Minnesota; Tehran University of Medical Sciences and Health Services; University of South Carolina; Universität Zürich; National Institute on Drug Abuse; University of Pennsylvania; Szegedi Tudományegyetem; BrainsWay; Massachusetts Institute of Technology; Pennsylvania State University","keywords":"Biomarker; Medicine; Drug development; MEDLINE; Clinical study design; Imaging biomarker; Addiction; Clinical trial; Psychology; Magnetic resonance imaging; Psychiatry; Internal medicine; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1204313,0.001452386,0.00348999,0.008050434,0.0006988895,0.006745696,0.002723841,0.002691547,0.00463412],"category_scores_gemma":[0.3062936,0.001381336,0.005743816,0.005669984,0.002740595,0.008166797,0.003300237,0.002623926,0.0005878424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001395658,"about_ca_system_score_gemma":0.002560191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002062515,"about_ca_topic_score_gemma":0.002142414,"domain_scores_codex":[0.933946,0.05220867,0.006056715,0.004166576,0.003286191,0.0003357708],"domain_scores_gemma":[0.5529752,0.4146444,0.0138998,0.01241856,0.005468227,0.0005936859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.003455197,0.0002386434,0.1273383,0.04386261,0.03087351,0.0009406084,0.00198337,0.03603992,0.001956398,0.06311572,0.007863163,0.6823324],"study_design_scores_gemma":[0.0009569752,0.004445685,0.123745,0.04910156,0.03190283,0.002407135,0.002127245,0.1170149,0.004326446,0.5602246,0.1028403,0.0009073369],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09970412,0.5446033,0.3196392,0.01795606,0.001287757,0.0007217185,0.004346932,0.0006447098,0.01109619],"genre_scores_gemma":[0.811191,0.06234438,0.1165062,0.003138451,0.0009867598,0.001399946,0.003452016,0.0001657046,0.0008155498],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1204313,"threshold_uncertainty_score":0.6369093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688429884089718,"score_gpt":0.3393752129726443,"score_spread":0.2924909141317471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}