{"id":"W4391603058","doi":"10.1007/s41981-024-00314-3","title":"Design and implementation of an automated DT-PhotoFluor radiosynthesis module for 18F-fluorination of aliphatic, branched chain amino acids","year":2024,"lang":"en","type":"article","venue":"Journal of Flow Chemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Simon Fraser University; TRIUMF","funders":"Canadian Cancer Society Research Institute; China Scholarship Council","keywords":"Radiosynthesis; Chemistry; Amino acid; Yield (engineering); Radiochemistry; Combinatorial chemistry; Cancer research; Biochemistry; Nuclear medicine; Positron emission tomography; Medicine; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004551175,0.0001257938,0.000250434,0.00004562404,0.00002370471,0.00001798264,0.000115676,0.0001030687,0.00002688665],"category_scores_gemma":[0.00006413594,0.0001137785,0.0001149374,0.00006911132,0.00004639534,0.00002063948,0.0000200795,0.00005382521,8.946831e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001680753,"about_ca_system_score_gemma":0.0001221517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003902983,"about_ca_topic_score_gemma":5.031472e-7,"domain_scores_codex":[0.9990754,0.00003442929,0.0004553252,0.0001560074,0.0001498321,0.0001290156],"domain_scores_gemma":[0.9992898,0.00003523812,0.0002726626,0.0001379451,0.0001927717,0.00007157901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111851,0.00004575518,0.00003975048,0.0003524039,0.000145821,0.000002809684,0.0001348133,0.0002638698,0.9776257,0.000007159056,0.0003522102,0.02091848],"study_design_scores_gemma":[0.0008446272,0.0002238957,0.0004293268,0.00005579849,0.0001268536,0.00007870723,0.0001872773,0.01912791,0.9779515,0.00003778143,0.0008323705,0.0001039046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670328,0.002530241,0.0300389,0.00004888275,0.0001138818,0.0001581857,0.00005101499,0.00001001634,0.00001600942],"genre_scores_gemma":[0.9745908,0.0003414662,0.02466963,0.00001293832,0.0002312427,0.00001026194,0.00004900669,0.00002084076,0.0000738277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02081457,"threshold_uncertainty_score":0.4639751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008831660589330947,"score_gpt":0.2873322301653584,"score_spread":0.2785005695760274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}