{"id":"W4391604125","doi":"10.1038/s41386-024-01811-8","title":"Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans","year":2024,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Centre National de la Recherche Scientifique; Fondation de France; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Major depressive disorder; Biomarker; Antidepressant; Depression (economics); Disease; Medicine; Bioinformatics; Psychiatry; Psychology; Internal medicine; Biology; Genetics; Mood; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002798788,0.001238251,0.0004485036,0.001593418,0.0002954584,0.0004273831,0.0004567189,0.0008010783,0.002133589],"category_scores_gemma":[0.0003261394,0.0003407058,0.0004546959,0.000403411,0.0004884606,0.0002152868,0.0005173787,0.001100228,0.0003610498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003845462,"about_ca_system_score_gemma":0.0002880707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265194,"about_ca_topic_score_gemma":0.002603117,"domain_scores_codex":[0.9997426,0.00005033256,0.00002785408,0.0000962652,0.00004570332,0.00003735308],"domain_scores_gemma":[0.9995983,0.00004226724,0.0002029215,0.0000454392,0.00002479858,0.0000862992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001745774,0.0003329577,0.005591406,0.00006205851,0.0001174338,0.0006475545,0.00008023105,0.0002368408,0.9855471,0.00103592,0.0004356078,0.004167109],"study_design_scores_gemma":[0.001811178,0.00461038,0.3212457,0.0002865964,0.001457559,0.01314829,0.0007269284,0.01483693,0.6223364,0.004937061,0.01441092,0.0001919594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867712,0.0006428464,0.008596122,0.0004063868,0.00007131018,0.00007086605,0.002488572,0.0001727337,0.000780049],"genre_scores_gemma":[0.982874,0.0009225433,0.009813551,0.0003104044,0.00002040058,0.0002312331,0.00231209,0.00009387139,0.003421906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002133589,"threshold_uncertainty_score":0.007137537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692766413238738,"score_gpt":0.3560267808543695,"score_spread":0.3290991167219821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}