{"id":"W4391605298","doi":"10.1016/j.cmi.2024.02.001","title":"Which trial do we need? Empiric Glycopeptides plus clindamycin versus Oxazolidinones for suspected toxic shock and necrotizing soft tissue infections","year":2024,"lang":"en","type":"letter","venue":"Clinical Microbiology and Infection","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Fulminant; Toxic shock syndrome; Medicine; Streptococcus pyogenes; Clindamycin; Septic shock; Empiric treatment; Soft tissue; Sepsis; Intensive care medicine; Staphylococcus aureus; Surgery; Antibiotics; Dermatology; Microbiology; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002158168,0.000436121,0.002461786,0.0005716872,0.000897947,0.002001398,0.0009750001,0.007808493,0.00847002],"category_scores_gemma":[0.01768435,0.0003189499,0.0009771582,0.0007611068,0.000936099,0.001690244,0.0004061071,0.006702343,0.002394223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002484956,"about_ca_system_score_gemma":0.001970657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983561,"about_ca_topic_score_gemma":0.008335136,"domain_scores_codex":[0.9988632,0.0006163381,0.0001653009,0.0000897538,0.0001420551,0.0001233289],"domain_scores_gemma":[0.9899179,0.00627406,0.0008963744,0.0001413021,0.000720003,0.002050397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.09880343,0.002310088,0.02077408,0.002416864,0.0008798923,0.01081624,0.0003049661,0.001566113,0.002963277,0.005130011,0.5820436,0.2719914],"study_design_scores_gemma":[0.1133267,0.02541501,0.06498975,0.00916913,0.00285526,0.02569387,0.002602609,0.007419492,0.002600324,0.03451405,0.7109079,0.0005059625],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04928201,0.05675574,0.0007465959,0.8360518,0.02899926,0.0003568458,0.0008232205,0.0001036061,0.02688086],"genre_scores_gemma":[0.2640299,0.02595608,0.003825234,0.6115687,0.08185463,0.0005924666,0.0006244991,0.00007322883,0.01147532],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00847002,"threshold_uncertainty_score":0.02833509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07673757405132632,"score_gpt":0.3960026082653569,"score_spread":0.3192650342140306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}