{"id":"W4391609906","doi":"10.1093/bjd/ljad498.033","title":"528 - Rapid skin clearance and itch improvement with upadacitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: results from a phase 3b head-to-head clinical trial (Heads Up)","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; University of Calgary","funders":"","keywords":"Dupilumab; Medicine; Atopic dermatitis; Dermatology; Clinical trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001181538,0.0008610988,0.001904,0.0002920358,0.0003736743,0.0009006573,0.0005087437,0.0008839841,0.006260933],"category_scores_gemma":[0.0007216168,0.0003441594,0.001939379,0.0002834369,0.0005277161,0.0006065528,0.0002595579,0.002007778,0.0009161378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000534859,"about_ca_system_score_gemma":0.0008250499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009662115,"about_ca_topic_score_gemma":0.003157767,"domain_scores_codex":[0.9996846,0.0001286019,0.00002169363,0.00005386498,0.00003398291,0.0000772729],"domain_scores_gemma":[0.9995947,0.00008359088,0.00008449489,0.00002761468,0.00004715113,0.0001624341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8666617,0.01952176,0.003232619,0.002261481,0.002697413,0.0001443861,0.0001528635,0.0007413271,0.01238937,0.0001459978,0.004901508,0.08714963],"study_design_scores_gemma":[0.8245434,0.1593306,0.01046505,0.0001094818,0.001423361,0.000194786,0.00005684632,0.000619125,0.00145624,0.000144727,0.00162601,0.00003048204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853309,0.007534111,0.0003197429,0.0005505049,0.0002543475,0.002107375,0.001504241,0.0001545405,0.002244317],"genre_scores_gemma":[0.9910284,0.002818615,0.0006562693,0.0009735906,0.0002125853,0.00136119,0.001309216,0.00001625069,0.001623989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006260933,"threshold_uncertainty_score":0.02094489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838879619263522,"score_gpt":0.3411368093519433,"score_spread":0.3127480131593081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}