{"id":"W4391611776","doi":"10.1111/pai.14077","title":"Expanding the molecular and phenotypic spectrum of CTLA‐4 insufficiency","year":2024,"lang":"en","type":"letter","venue":"Pediatric Allergy and Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; BC Children's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Georgia Clinical and Translational Science Alliance; Vanderbilt Institute for Clinical and Translational Research; Michael Smith Health Research BC; National Cancer Institute; Vanderbilt-Ingram Cancer Center; Vanderbilt University","keywords":"Medicine; Immunology; CTLA-4; Hypogammaglobulinemia; Common variable immunodeficiency; Cytotoxic T cell; Autoimmunity; Immunodeficiency; Immune system; T cell; Genetics; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003159459,0.0005526887,0.000782011,0.0004479382,0.0004097713,0.00004183357,0.0006206678,0.00143437,0.0002565699],"category_scores_gemma":[0.00008507677,0.0004044524,0.0001978994,0.0004109569,0.001229538,0.00008257578,0.0005351536,0.002637826,0.0001292241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002628797,"about_ca_system_score_gemma":0.000144974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000215298,"about_ca_topic_score_gemma":0.000001939421,"domain_scores_codex":[0.9973716,0.0003375692,0.0007002889,0.000716456,0.00008231783,0.0007917397],"domain_scores_gemma":[0.9986283,0.0003622997,0.00035569,0.0005951604,0.00005213872,0.000006422053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001126308,0.001539679,0.0008902471,0.003938028,0.01614991,0.001004912,0.02302091,0.00005750589,0.1043719,0.08193631,0.70836,0.05760427],"study_design_scores_gemma":[0.001216732,0.0007206391,0.001721189,0.00009442344,0.0005445413,0.0004436186,0.0006132681,0.000006333773,0.002875539,0.005065988,0.9858125,0.0008851986],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1360872,0.7751514,0.0001018574,0.08322425,0.002431879,0.0003447785,0.00004428111,0.00009941324,0.002515004],"genre_scores_gemma":[0.8909011,0.0589467,0.00001171895,0.04264668,0.0002263171,0.00008793493,0.000324183,0.0001336011,0.006721723],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.754814,"threshold_uncertainty_score":0.999862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005755052551480361,"score_gpt":0.2036905682967621,"score_spread":0.1979355157452818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}