{"id":"W4391611776","doi":"10.1111/pai.14077","title":"Expanding the molecular and phenotypic spectrum of CTLA‐4 insufficiency","year":2024,"lang":"en","type":"letter","venue":"Pediatric Allergy and Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; BC Children's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Georgia Clinical and Translational Science Alliance; Vanderbilt Institute for Clinical and Translational Research; Michael Smith Health Research BC; National Cancer Institute; Vanderbilt-Ingram Cancer Center; Vanderbilt University","keywords":"Medicine; Immunology; CTLA-4; Hypogammaglobulinemia; Common variable immunodeficiency; Cytotoxic T cell; Autoimmunity; Immunodeficiency; Immune system; T cell; Genetics; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003933646,0.00127174,0.0005338798,0.00138782,0.0004701416,0.0005821785,0.0005543864,0.0006652352,0.003035827],"category_scores_gemma":[0.001258556,0.0002090407,0.0003959866,0.0007023983,0.0007821781,0.0005795103,0.001083227,0.0008330132,0.0006027851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003049605,"about_ca_system_score_gemma":0.0002845339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005477677,"about_ca_topic_score_gemma":0.0002890669,"domain_scores_codex":[0.9996247,0.00006136459,0.000054447,0.0000858161,0.00007821154,0.00009540894],"domain_scores_gemma":[0.9995005,0.0001916092,0.0001117903,0.00003276374,0.00007515956,0.0000881005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0005302724,0.0002180284,0.1725651,0.0002322269,0.00005140701,0.6932352,0.0005124945,0.0007300155,0.06852501,0.00287972,0.001765715,0.05875491],"study_design_scores_gemma":[0.00003776265,0.0002371965,0.05714456,0.0001106023,0.00006827304,0.9290698,0.0002514557,0.0006784335,0.005911076,0.001095301,0.00537442,0.00002116843],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715049,0.007191879,0.004775176,0.001200768,0.00009285523,0.00008717769,0.00041869,0.0002538604,0.0144747],"genre_scores_gemma":[0.9922002,0.003001593,0.002680188,0.000451454,0.0002293719,0.00002253175,0.0003724341,0.00004622121,0.0009960525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003035827,"threshold_uncertainty_score":0.0101558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005755052551480361,"score_gpt":0.2036905682967621,"score_spread":0.1979355157452818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}