{"id":"W4391612020","doi":"10.1038/s41380-023-02392-6","title":"White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Mental Health & Substance Use Services; McMaster University; Hotchkiss Brain Institute; University of Calgary; St. Joseph’s Healthcare Hamilton; University of British Columbia; Hospital for Sick Children; BC Children's Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Research Foundation; Instituto de Salud Carlos III; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Japan Society for the Promotion of Science; Ministry of Science and ICT, South Korea; Institute for Information and Communications Technology Promotion; The Wellcome Trust DBT India Alliance; National Center for Advancing Translational Sciences; National Research Foundation of Korea; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ministry of Education, Culture, Sports, Science and Technology; BC Children's Hospital; International OCD Foundation; Michael Smith Health Research BC; BC Children’s Hospital Foundation; Department of Science and Technology, Ministry of Science and Technology, India; Samsung; Department of Biotechnology, Ministry of Science and Technology, India; Wellcome Trust; Seoul National University; European Commission; Japan Agency for Medical Research and Development; U.S. Department of Health and Human Services","keywords":"White matter; Obsessive compulsive; Psychology; Diffusion MRI; White (mutation); Psychiatry; Medicine; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004520258,0.0006160223,0.0006845372,0.001278438,0.0006318369,0.000909104,0.0007649744,0.0006027148,0.0006020241],"category_scores_gemma":[0.01235604,0.0003703982,0.0008166077,0.001142857,0.0006380593,0.0005707695,0.001502741,0.0006481879,0.0003344026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003993376,"about_ca_system_score_gemma":0.0004475308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01410756,"about_ca_topic_score_gemma":0.01725077,"domain_scores_codex":[0.9984053,0.0005058013,0.000186994,0.0006042757,0.0002027328,0.00009501723],"domain_scores_gemma":[0.9940968,0.001938048,0.001169607,0.0015932,0.0009133585,0.0002890503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003901364,0.00009901026,0.9696181,0.0000480857,0.0007150234,0.0001227045,0.0009381718,0.002861051,0.002231932,0.0001275879,0.001200438,0.02164762],"study_design_scores_gemma":[0.00004550772,0.0001579263,0.983193,0.00003794076,0.0002707252,0.0006414549,0.0004499943,0.01245031,0.001168718,0.0005068858,0.001038142,0.00003934956],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981103,0.0001079522,0.001016003,0.00003334407,0.000005040616,0.00001091914,0.0005669447,0.00003200436,0.0001175273],"genre_scores_gemma":[0.9947299,0.00008861545,0.001771354,0.00002570371,0.000008133855,0.00002814361,0.003198298,0.00003341553,0.0001163902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01410756,"threshold_uncertainty_score":0.0280509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006927403428821786,"score_gpt":0.2755850698400568,"score_spread":0.268657666411235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}