{"id":"W4391617084","doi":"10.1016/j.envint.2024.108479","title":"Sodium butyrate alleviates lead-induced neuroinflammation and improves cognitive and memory impairment through the ACSS2/H3K9ac/BDNF pathway","year":2024,"lang":"en","type":"article","venue":"Environment International","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Neurotoxicity; Butyrate; Neuroinflammation; Butyric acid; Chemistry; Sodium butyrate; Elevated plus maze; Pharmacology; Endocrinology; Internal medicine; Anxiety; Toxicity; Medicine; Inflammation; Biochemistry; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827585,0.0002284908,0.0001170661,0.00007961028,0.0002139193,0.0003829951,0.0001719132,0.00005056164,0.0003747659],"category_scores_gemma":[0.00008572139,0.00017497,0.00005293698,0.00005853954,0.0001112921,0.0005932513,0.0001926575,0.0002290119,0.0002736521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004012793,"about_ca_system_score_gemma":0.00002140739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003932795,"about_ca_topic_score_gemma":0.000001635076,"domain_scores_codex":[0.9982172,0.000162882,0.0003166508,0.0006222532,0.0004855607,0.0001954573],"domain_scores_gemma":[0.9993281,0.0003324086,0.0001070004,0.000156794,0.00001294404,0.00006271413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000332348,0.00003569198,0.00001546853,0.00001515181,0.00001324005,0.00003112084,0.0007489736,0.00003913205,0.9818763,0.01100922,0.00008210589,0.006100326],"study_design_scores_gemma":[0.0004835431,0.0001806969,0.0007303911,0.00003005025,0.0000160436,0.00009782306,0.0001877517,0.01374879,0.9756604,0.002338227,0.00632297,0.0002033539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890804,0.00009973334,0.0005356082,0.006377971,0.000929773,0.0006049795,0.00005480872,0.0001360849,0.0021807],"genre_scores_gemma":[0.9936493,0.0006591871,0.00007528806,0.001517946,0.0002022948,0.00008801727,0.00002324093,0.00003196691,0.003752746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01370966,"threshold_uncertainty_score":0.7135069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02631950750577808,"score_gpt":0.2475549724428796,"score_spread":0.2212354649371016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}