{"id":"W4391618252","doi":"10.1056/nejmoa2308713","title":"An Oral Interleukin-23–Receptor Antagonist Peptide for Plaque Psoriasis","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; Innovaderm (Canada); Dermatrials Research; Probity Medical Research","funders":"Janssen Research and Development","keywords":"Interleukin 1 receptor antagonist; Psoriasis; Receptor antagonist; Interleukin 23; Medicine; Antagonist; Cytokine; Immune system; Monoclonal antibody; Immunology; Receptor; Peptide; Interleukin; Pharmacology; Antibody; Internal medicine; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006745138,0.000468158,0.001053052,0.0003099514,0.0002397205,0.000379145,0.000396634,0.0005045807,0.004518411],"category_scores_gemma":[0.0004292701,0.0002585743,0.0005088047,0.000232259,0.0003862059,0.0002589567,0.0002194542,0.001246975,0.0007412056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002912756,"about_ca_system_score_gemma":0.0006431671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401847,"about_ca_topic_score_gemma":0.0007885405,"domain_scores_codex":[0.9997688,0.00007555017,0.00001905068,0.00003537289,0.00006518325,0.00003603621],"domain_scores_gemma":[0.99977,0.00005826047,0.00005448068,0.00001387722,0.00001288564,0.00009053071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3588014,0.03079467,0.007155148,0.004403507,0.001605582,0.000897065,0.0002022702,0.001846104,0.1707979,0.0007979019,0.005576788,0.4171218],"study_design_scores_gemma":[0.5896021,0.3633225,0.02235711,0.0002160616,0.001072804,0.001568782,0.0000613268,0.001158892,0.01158624,0.0003842397,0.008620945,0.00004901622],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875066,0.008039879,0.0005557156,0.0002646684,0.00020726,0.001144996,0.0001927593,0.00005550434,0.002032586],"genre_scores_gemma":[0.9902841,0.004865011,0.001630441,0.0004489848,0.0002830588,0.0008154602,0.000318377,0.000009848857,0.001344705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004518411,"threshold_uncertainty_score":0.01511562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02174180951233102,"score_gpt":0.2879754072596409,"score_spread":0.2662335977473099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}