{"id":"W4391639779","doi":"10.1124/pharmrev.120.000007","title":"New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview","year":2024,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Agencia Estatal de Investigación; European Regional Development Fund; National Health and Medical Research Council; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Biogen; Idorsia Pharmaceuticals; H. Lundbeck A/S; Gedeon Richter; Dainippon Sumitomo Pharma","keywords":"Lithium (medication); Mechanism (biology); Bipolar disorder; Neuroscience; Neuroprotection; Repurposing; GSK-3; Treatment of bipolar disorder; Mood disorders; Medicine; Drug repositioning; Bioinformatics; Pharmacology; Psychology; Drug; Psychiatry; Signal transduction; Biology; Mania; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009728194,0.000662838,0.003860322,0.0001790266,0.00004000016,0.0000133041,0.0003662508,0.0004017806,0.001028858],"category_scores_gemma":[0.0001685342,0.0002823579,0.0008247403,0.0009113554,0.000211288,0.00005365411,0.0002447103,0.001261432,0.0001689433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007892041,"about_ca_system_score_gemma":0.0002297251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005639462,"about_ca_topic_score_gemma":0.000008232228,"domain_scores_codex":[0.9955236,0.001611357,0.001446837,0.0007839588,0.0001801599,0.0004541403],"domain_scores_gemma":[0.9983605,0.0007058808,0.0004328307,0.0002600501,0.00003290296,0.0002077972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005058859,0.0004958292,0.00003496142,0.02447881,0.0002087712,0.0001380595,0.00004093363,2.429176e-8,0.0000228503,0.0006449889,0.006724799,0.9671594],"study_design_scores_gemma":[0.0008101261,0.00104591,0.0000520078,0.004540597,0.00948431,0.0004708283,0.000004262116,0.000001279189,0.000002381729,0.0001521115,0.9832202,0.0002160319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008740576,0.9919232,0.00001259881,0.0006880987,0.0005049816,0.00494393,0.00003201162,0.00004204875,0.001844431],"genre_scores_gemma":[0.00001819747,0.9964573,0.0003267572,0.001691876,0.0002355949,0.000915913,0.00006093123,0.00002779194,0.0002656112],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9764954,"threshold_uncertainty_score":0.9999629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1221344262578446,"score_gpt":0.4627648071782047,"score_spread":0.3406303809203601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}