{"id":"W4391642495","doi":"10.1002/cmdc.202300705","title":"Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics","year":2024,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Research Manitoba","keywords":"Neurodegeneration; Chemistry; Small molecule; Computational biology; Drug discovery; Nanotechnology; Medicine; Biology; Biochemistry; Materials science; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000889248,0.001017644,0.0007198728,0.0008353067,0.0005762159,0.001457126,0.001062886,0.001509205,0.01000958],"category_scores_gemma":[0.0005398034,0.0004943718,0.0007497175,0.0008245367,0.001111665,0.002463769,0.001448651,0.002846449,0.004317333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009459371,"about_ca_system_score_gemma":0.0007291308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005900195,"about_ca_topic_score_gemma":0.001073262,"domain_scores_codex":[0.999557,0.00009269354,0.0000288357,0.0001043464,0.0001610068,0.00005616231],"domain_scores_gemma":[0.9997408,0.00008062344,0.00006038728,0.00002503349,0.00006045839,0.00003276162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005070094,0.001007686,0.0004453748,0.009494104,0.0002139552,0.001016364,0.0003301227,0.00695578,0.2164297,0.1268787,0.02605666,0.6106645],"study_design_scores_gemma":[0.0002082461,0.001933849,0.000625902,0.0007651726,0.0001511295,0.001183711,0.0001546205,0.008342738,0.07939693,0.03876695,0.8683655,0.0001052612],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02817764,0.7567286,0.1014888,0.01293341,0.002265948,0.0007079873,0.0007196997,0.0007564835,0.09622159],"genre_scores_gemma":[0.1897126,0.7272568,0.04116229,0.007641133,0.0014251,0.0008650742,0.0007518426,0.00008515678,0.0310999],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01000958,"threshold_uncertainty_score":0.03348541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1506823054091085,"score_gpt":0.3338122527652641,"score_spread":0.1831299473561556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}