{"id":"W4391645512","doi":"10.26434/chemrxiv-2024-l0vll","title":"Isolation, Identification, and Characterization of a Serine Protease with Anti-nociceptive Activity from the Gut Bacterium, Faecalibacterium prausnitzii","year":2024,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"Faecalibacterium prausnitzii; Isolation (microbiology); Identification (biology); Microbiology; Serine protease; Protease; Biology; Biochemistry; Feces; Enzyme; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002123279,0.0003933582,0.000303973,0.0002134373,0.0001438611,0.0004017368,0.0001948089,0.0004629958,0.000368668],"category_scores_gemma":[0.0003408595,0.00009304189,0.0002361106,0.000258702,0.0002236009,0.0002579203,0.0002467026,0.0004999245,0.0003447084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032876,"about_ca_system_score_gemma":0.0002895896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000849024,"about_ca_topic_score_gemma":0.0006096163,"domain_scores_codex":[0.999862,0.00001714632,0.00001339691,0.00003092994,0.00005160019,0.00002500138],"domain_scores_gemma":[0.9999099,0.00002290147,0.00002374418,0.00001072662,0.00001774698,0.00001503291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004515625,0.00001253824,0.0002662234,0.00003613748,0.000003926202,0.00007735546,0.00001181318,0.00004764905,0.9979087,0.00005263184,0.00003485341,0.001503022],"study_design_scores_gemma":[0.00001793799,0.0001453452,0.01181111,0.000007392227,0.00001553832,0.0007409152,0.00003830839,0.001180386,0.982601,0.0000973697,0.003340325,0.000004420458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734268,0.004180556,0.01812813,0.0007614432,0.0001314296,0.00008106336,0.00163179,0.0000767816,0.001582039],"genre_scores_gemma":[0.9556386,0.003161343,0.02865036,0.0001701311,0.0000602366,0.00005497471,0.006066161,0.00005415575,0.006144042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000849024,"threshold_uncertainty_score":0.001688123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009173357812824252,"score_gpt":0.2305245187450326,"score_spread":0.2213511609322083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}