{"id":"W4391646095","doi":"10.1101/2024.02.07.579162","title":"Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of British Columbia; Hospital for Sick Children; Princess Margaret Cancer Centre; BC Children's Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Genentech; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; Mitacs; Michael Smith Health Research BC; BC Children's Hospital; Massachusetts General Hospital; McGill University; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Huntingtin; RNA; Nucleic acid; Huntingtin Protein; Cell biology; Mutant; RNA-binding protein; Biology; Gene knockdown; Molecular biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137575,0.0002410831,0.0001810731,0.0001744903,0.0003470997,0.0003244887,0.0001728452,0.0002920267,0.003730662],"category_scores_gemma":[0.000243251,0.0001474302,0.0002866367,0.0001107956,0.0001557567,0.0002232324,0.0003518283,0.0003263123,0.001383654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981732,"about_ca_system_score_gemma":0.0001324679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004700771,"about_ca_topic_score_gemma":0.0008316851,"domain_scores_codex":[0.9998636,0.00001309837,0.00001049455,0.00004693887,0.00004962955,0.0000163026],"domain_scores_gemma":[0.9998523,0.00002195841,0.00005038184,0.0000122502,0.00001709539,0.00004606108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001440861,0.00001014414,0.001722099,0.00008313447,0.00001259505,0.0004378346,0.00003270711,0.00007441346,0.9941682,0.0002316601,0.0003717307,0.002711426],"study_design_scores_gemma":[0.00003165712,0.0002796657,0.07121085,0.00003775796,0.00004640298,0.003462947,0.0001354217,0.004108554,0.9060674,0.0007840838,0.01380689,0.00002843805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856462,0.002363857,0.006773548,0.0002787798,0.0001466547,0.00003913516,0.0011013,0.0002735778,0.003377058],"genre_scores_gemma":[0.9826003,0.0005758845,0.005203167,0.0001936766,0.00004440124,0.00002319718,0.002320414,0.00008013815,0.008958859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003730662,"threshold_uncertainty_score":0.01248026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749252981538766,"score_gpt":0.2617872474625388,"score_spread":0.2242947176471512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}