{"id":"W4391649897","doi":"10.1002/1878-0261.13596","title":"Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the <scp>BRAF</scp> /Pten mouse melanoma model","year":2024,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"PTEN; Cancer research; Melanoma; CD8; Tumor-infiltrating lymphocytes; Biology; Tumor microenvironment; Immune system; Immunotherapy; T cell; Immune checkpoint; Infiltration (HVAC); Cytotoxic T cell; PI3K/AKT/mTOR pathway; Immunology; Cell biology; Signal transduction; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005632419,0.0002986239,0.0002964375,0.0000937493,0.00009349047,0.00007175357,0.0004413103,0.0003719332,0.00001133598],"category_scores_gemma":[0.0003799241,0.0002376086,0.0001866791,0.0002847908,0.0001705389,0.000008397222,0.0001894499,0.0001956565,0.00002871779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001505649,"about_ca_system_score_gemma":0.0004919513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003588363,"about_ca_topic_score_gemma":0.0008215188,"domain_scores_codex":[0.9977929,0.000469031,0.0003867635,0.0006544945,0.0001555546,0.0005412496],"domain_scores_gemma":[0.9991777,0.0001314523,0.00008264936,0.0004534856,0.00006593154,0.00008880775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009500663,0.0004320405,0.004963466,0.00007490085,0.000212295,0.001370157,0.0004164786,0.007895947,0.9497144,0.01327109,0.007415955,0.01413831],"study_design_scores_gemma":[0.006831978,0.007467218,0.009345898,0.0001894147,0.0004892739,0.006793533,0.004521365,0.1966765,0.2663306,0.009816037,0.4901319,0.001406219],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810044,0.004816305,0.005687634,0.000379231,0.0001359407,0.0003134361,0.00007316458,0.00005476275,0.007535175],"genre_scores_gemma":[0.9950727,0.00015005,0.0008859452,0.003074676,0.0002064534,0.0001262663,0.0002759765,0.000032811,0.0001750717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6833837,"threshold_uncertainty_score":0.9689398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016716597828526,"score_gpt":0.2695963741071832,"score_spread":0.2594292081288979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}