{"id":"W4391650478","doi":"10.3389/fmolb.2024.1354627","title":"Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans","year":2024,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Trace Elements in Health","field":"Nursing","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Tokyo Women's Medical University; Deutsche Forschungsgemeinschaft; Canadian Institute for Advanced Research","keywords":"Ceruloplasmin; Homeostasis; Caenorhabditis elegans; Mutant; Transporter; Autophagy; Chemistry; Gene; Intracellular; Cell biology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008798215,0.0001894522,0.0002491294,0.0009126888,0.00007833511,0.00016834,0.0001620309,0.0001130398,0.000008558584],"category_scores_gemma":[0.0001307784,0.0001895026,0.00002434471,0.001238331,0.0004787643,0.0003639655,0.00005623216,0.0002844065,0.000001939566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003149725,"about_ca_system_score_gemma":0.0001070746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007097095,"about_ca_topic_score_gemma":0.001374562,"domain_scores_codex":[0.997896,0.0002160173,0.0003823487,0.0006782523,0.000318661,0.0005087151],"domain_scores_gemma":[0.9996008,0.00007463238,0.00005236588,0.0001607131,0.00001287435,0.00009866712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001168005,0.0001177485,0.8601016,0.0003989737,0.00001583621,0.0003190711,0.004818255,0.0001605575,0.02325368,0.0004294399,0.00255205,0.107716],"study_design_scores_gemma":[0.006064553,0.001725186,0.7830255,0.002816133,0.0000964987,0.0001689699,0.02499792,0.04827226,0.08986454,0.01414695,0.02647997,0.002341527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831335,0.008331005,0.001939837,0.003236452,0.002738668,0.000430994,0.00003319279,0.00004404229,0.0001123316],"genre_scores_gemma":[0.9888145,0.0002547106,0.01040696,0.0004222316,0.00001790581,0.00002976898,0.00000396103,0.00001842278,0.00003149756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1053745,"threshold_uncertainty_score":0.7727691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01352609037729427,"score_gpt":0.278627314184371,"score_spread":0.2651012238070767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}