{"id":"W4391656787","doi":"10.1016/j.bpj.2023.11.563","title":"Heat capacity changes associated with G-quadruplex unfolding","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Heat capacity; G-quadruplex; Enthalpy; Differential scanning calorimetry; Chemistry; Thermodynamics; Entropy (arrow of time); DNA; Guanine; Gibbs free energy; Crystallography; Physics; Nucleotide; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604192,0.0003498141,0.0002451132,0.0004333195,0.0002962414,0.0003463307,0.0003332406,0.0003698565,0.004990314],"category_scores_gemma":[0.0007925372,0.0001756079,0.0002373074,0.0004295861,0.0005624705,0.0004676284,0.0002168906,0.000957179,0.0004172286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000559569,"about_ca_system_score_gemma":0.0002335592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001487034,"about_ca_topic_score_gemma":0.0007624854,"domain_scores_codex":[0.9997807,0.00003829596,0.000009121714,0.00004748678,0.00004307928,0.00008134401],"domain_scores_gemma":[0.9993916,0.0001883692,0.0001337769,0.00005042942,0.0001200233,0.0001158919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001430178,0.00007455691,0.001383837,0.00006075572,0.00003761319,0.000141468,0.0001518521,0.0004922014,0.9928923,0.00031643,0.0002778735,0.002740986],"study_design_scores_gemma":[0.0000190621,0.0002764373,0.0218953,0.000007946583,0.00001785328,0.0000848284,0.00007298878,0.002473999,0.974426,0.0001344894,0.000568161,0.0000229878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938008,0.0004408948,0.002317749,0.0001034787,0.00003890184,0.00004864042,0.0008837558,0.0001446752,0.002221035],"genre_scores_gemma":[0.9978179,0.00008167596,0.0004165402,0.00003814711,0.000009943669,0.00002937181,0.0006020799,0.00002264631,0.0009816334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004990314,"threshold_uncertainty_score":0.01669425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319394402500529,"score_gpt":0.2343625181684785,"score_spread":0.2211685741434732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}