{"id":"W4391657013","doi":"10.1016/j.bpj.2023.11.783","title":"Regulation of cardiac Nav1.5 channel gating and drug binding by the beta-1 subunit","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Depolarization; Biophysics; Gating; Protein subunit; Chemistry; Sodium channel; BETA (programming language); Membrane potential; Biochemistry; Cell biology; Biology; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833156,0.0001870593,0.0002791103,0.0001299717,0.0002313749,0.0008003192,0.000298923,0.0002891068,0.002256663],"category_scores_gemma":[0.0007041607,0.0002214495,0.0001824116,0.00007860307,0.0003692266,0.0004575261,0.0003629226,0.0005575829,0.0004673975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898173,"about_ca_system_score_gemma":0.0001615376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005111841,"about_ca_topic_score_gemma":0.0007176306,"domain_scores_codex":[0.9997197,0.00007401986,0.00001600895,0.00004467595,0.00005758672,0.00008808789],"domain_scores_gemma":[0.9997284,0.0001140578,0.00005624968,0.00002258613,0.0000249876,0.00005364711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005864097,0.00005200559,0.001071659,0.00003941752,0.00001198363,0.0001054154,0.0001020905,0.0001493023,0.9937277,0.0006117249,0.0002094333,0.003332935],"study_design_scores_gemma":[0.0003425134,0.0007776686,0.1475961,0.00009839399,0.00007713324,0.001222161,0.000521895,0.01608432,0.8256248,0.001490085,0.006112904,0.00005204459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927302,0.002043934,0.001431862,0.0003521394,0.00005174585,0.00001041069,0.00008846532,0.00004199004,0.003249217],"genre_scores_gemma":[0.9981145,0.0005376125,0.0004102682,0.0001408011,0.00001596238,0.000008734127,0.00008038259,0.00002442702,0.0006673551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002256663,"threshold_uncertainty_score":0.007549286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101312598018424,"score_gpt":0.2529294410482114,"score_spread":0.242798181246369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}