{"id":"W4391658156","doi":"10.1182/bloodadvances.2023011743","title":"Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Novo Nordisk; Moderna; Argenx; Incyte; bluebird bio; Celgene; Silence Therapeutics; Sanofi; Alexion Pharmaceuticals; Amgen; Pfizer; Swedish Orphan Biovitrum; Apellis Pharmaceuticals; Agios Pharmaceuticals; Bristol-Myers Squibb","keywords":"Erythropoiesis; Pyruvate kinase deficiency; Pyruvate kinase; Ineffective erythropoiesis; Internal medicine; Endocrinology; Medicine; Metabolism; Anemia; Glycolysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004644629,0.0003692922,0.0008045408,0.0001488549,0.0001351552,0.0002612812,0.0002200958,0.0002512431,0.002985608],"category_scores_gemma":[0.0006680663,0.0001121549,0.0004010423,0.0001458968,0.000124178,0.0002493243,0.0001627217,0.0007729469,0.0002633912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215363,"about_ca_system_score_gemma":0.0002282162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002461129,"about_ca_topic_score_gemma":0.000665827,"domain_scores_codex":[0.9998968,0.00004087772,0.00001366628,0.00001514706,0.00001495049,0.00001864142],"domain_scores_gemma":[0.9997713,0.00005733405,0.00007253062,0.00001285241,0.00002245861,0.00006352732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3544902,0.01090269,0.02614333,0.003816304,0.002878477,0.0008570408,0.00027397,0.001787593,0.07009795,0.0003979396,0.01181201,0.5165425],"study_design_scores_gemma":[0.281209,0.3685073,0.289958,0.0009105492,0.004196241,0.005332274,0.0003717927,0.006074475,0.02194088,0.0007488363,0.02066209,0.00008876235],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819362,0.01487312,0.0002957119,0.0003525743,0.00009890014,0.0001671987,0.0003636576,0.0001223792,0.001790221],"genre_scores_gemma":[0.9955194,0.002561491,0.000436862,0.000368839,0.00006090973,0.00008191276,0.0003524992,0.000005092027,0.0006130789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002985608,"threshold_uncertainty_score":0.009987831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003328810931262844,"score_gpt":0.223580798949117,"score_spread":0.2202519880178541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}