{"id":"W4391658342","doi":"10.1016/j.bpj.2023.11.3176","title":"Inhibition of HCN1 by norquetiapine—an active metabolite of the atypical anti-psychotic drug quetiapine","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Quetiapine; Schizophrenia (object-oriented programming); Bipolar disorder; Drug; Pharmacology; Quetiapine Fumarate; Active metabolite; Anxiety; Antipsychotic; Metabolite; Atypical antipsychotic; Chemistry; Psychosis; Neuroscience; Medicine; Psychiatry; Psychology; Biochemistry; Lithium (medication)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117227,0.0001797721,0.0001979274,0.0001229508,0.0001558585,0.0002334034,0.0003828726,0.0002316407,0.001416314],"category_scores_gemma":[0.0002632664,0.0001150687,0.000158057,0.0000853011,0.0002214128,0.000129564,0.0001110694,0.0004390374,0.0002217441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005231815,"about_ca_system_score_gemma":0.0003341228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003840099,"about_ca_topic_score_gemma":0.006216934,"domain_scores_codex":[0.9999135,0.00002163289,0.000006727196,0.000008990212,0.00001685163,0.00003244717],"domain_scores_gemma":[0.99992,0.00002693374,0.00001241428,0.000007513386,0.000008210754,0.00002489287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002999869,0.0001072741,0.0003766033,0.00006703626,0.00002587363,0.000254176,0.00004770608,0.0002105333,0.9892383,0.0007375811,0.0004677759,0.005467339],"study_design_scores_gemma":[0.0005443819,0.00198406,0.01055879,0.00001480592,0.00004818963,0.0007987585,0.00009423651,0.004002471,0.974312,0.0002010893,0.007424009,0.00001726321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942439,0.001086891,0.0006610638,0.0002206845,0.00007631692,0.00002715686,0.0002132598,0.00005145305,0.003419223],"genre_scores_gemma":[0.996881,0.0007023782,0.0004716664,0.00005110113,0.00001933978,0.00001182781,0.0001950354,0.000007406207,0.001660334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003840099,"threshold_uncertainty_score":0.007635474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006381454928229249,"score_gpt":0.2462569726704482,"score_spread":0.2398755177422189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}