{"id":"W4391659206","doi":"10.1016/j.bpj.2023.11.2457","title":"Structure and dynamics of chloride ion conduction in CFTR","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Cystic fibrosis transmembrane conductance regulator; Chloride channel; Gating; Cystic fibrosis; Conductance; Molecular dynamics; Biophysics; Chemistry; Transmembrane protein; Secretion; Thermal conduction; Ion channel; Ion transporter; Regulator; Ion; Biochemistry; Materials science; Membrane; Biology; Physics; Computational chemistry; Genetics; Condensed matter physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999854,0.0001349223,0.0002131766,0.0002403276,0.0006964394,0.0007788609,0.000434686,0.0004185951,0.001614844],"category_scores_gemma":[0.000720229,0.000220485,0.0001758369,0.0002026541,0.0008526869,0.001134869,0.0003125741,0.0008836486,0.000271442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005340243,"about_ca_system_score_gemma":0.0003314653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001798406,"about_ca_topic_score_gemma":0.001440987,"domain_scores_codex":[0.9999446,0.000008365017,0.000002962613,0.00001531138,0.00001203332,0.00001677974],"domain_scores_gemma":[0.9997901,0.0000876972,0.00003509445,0.00001406736,0.00002634521,0.00004679397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001263136,0.000280582,0.008338547,0.0002178786,0.00004098971,0.0007112965,0.001232299,0.02979807,0.9040604,0.03973876,0.001324183,0.01299395],"study_design_scores_gemma":[0.0003145468,0.001273657,0.1063218,0.0001500849,0.00008609246,0.001481532,0.002210325,0.5699381,0.2564186,0.05364322,0.007910316,0.0002517283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949214,0.0005211031,0.002113989,0.0003533541,0.00001667298,0.000004867862,0.00007514186,0.00003433182,0.00195916],"genre_scores_gemma":[0.9987104,0.0002292441,0.0005028154,0.00002805661,0.000008787346,0.000003842357,0.000104753,0.00001165634,0.0004005047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798406,"threshold_uncertainty_score":0.005402148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230234259003505,"score_gpt":0.3103130229832617,"score_spread":0.2980106803932266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}