{"id":"W4391680182","doi":"10.1038/s41380-024-02442-7","title":"Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; Queensland Brain Institute; University of California, Irvine; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Instituto de Investigación Marqués de Valdecilla; Instituto de Salud Carlos III; Ohio State University; Pontificia Universidad Católica de Chile; Hôpitaux Universitaires de Genève; University of Cape Town; Centro de Investigación Biomédica en Red de Salud Mental; Universität Zürich; University of Queensland; Emory University; Westfälische Wilhelms-Universität Münster; Universität zu Lübeck; Philipps-Universität Marburg; Forschungszentrum Jülich; Technische Universität Dresden; University of Melbourne; U.S. Department of Veterans Affairs; University of New South Wales; National Institute of Mental Health; Universität Basel; McGill University; Universidad de Antioquia; Universidad de Sevilla; University of Southern California; Hunter Medical Research Institute; Università degli Studi di Napoli Federico II","keywords":"Schizophrenia (object-oriented programming); Connectome; Neuroscience; Generalizability theory; Psychosis; Psychology; DISC1; Human Connectome Project; Disease; Functional connectivity; Biology; Psychiatry; Medicine; Developmental psychology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003443124,0.0003042445,0.0003016499,0.0004478292,0.0002973497,0.000214811,0.0002829747,0.00006918739,0.0001234734],"category_scores_gemma":[0.00149843,0.0002854611,0.0001721113,0.001226245,0.0001040065,0.0001445373,0.0001856603,0.0008062663,0.0001920977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006585287,"about_ca_system_score_gemma":0.0001656737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001735671,"about_ca_topic_score_gemma":0.00162874,"domain_scores_codex":[0.9971128,0.0004444994,0.0003738744,0.001071511,0.0004998099,0.0004975262],"domain_scores_gemma":[0.9980647,0.001394591,0.00003467999,0.0003680218,0.00002708014,0.0001109502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00240841,0.01367601,0.06902531,0.000743939,0.0007615302,0.006596659,0.01891149,0.01299967,0.5131802,0.3310866,0.02351416,0.00709603],"study_design_scores_gemma":[0.03109556,0.007735279,0.4167212,0.002405774,0.001150381,0.002548311,0.01520864,0.1044604,0.05441036,0.2829737,0.07189775,0.009392664],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669391,0.001057883,0.008078518,0.01924196,0.001772966,0.000796077,0.00005384834,0.0003636717,0.001695994],"genre_scores_gemma":[0.9934915,0.000004991067,0.001054118,0.004754429,0.0002284139,0.0002051168,0.000003840154,0.00005455008,0.000203048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4587698,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233213295078173,"score_gpt":0.2734644727421958,"score_spread":0.261132339791414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}