{"id":"W4391681169","doi":"10.1038/s41564-024-01603-2","title":"Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa","year":2024,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Warwick; Research Councils UK; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; G. Harold and Leila Y. Mathers Foundation; Universities Space Research Association; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Medical Research Council; Howard Hughes Medical Institute; California Institute of Technology; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; McMaster University; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Peptidoglycan; Lipid II; Pseudomonas aeruginosa; Biogenesis; Lipid A; Extracellular; Enzyme; Chemistry; Glycan; Cell biology; Biochemistry; Dimer; Cell wall; Bacterial cell structure; Monomer; Bacteria; Biophysics; Biology; Gene; Glycoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001431358,0.0002531595,0.0002365942,0.0001229973,0.0002020743,0.0004449043,0.0002983297,0.0002375752,0.0004245423],"category_scores_gemma":[0.0002622711,0.0001900879,0.0001613811,0.00007409772,0.0004414124,0.0003358877,0.0003340741,0.000442824,0.0001900411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005156194,"about_ca_system_score_gemma":0.0002605914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620415,"about_ca_topic_score_gemma":0.001360289,"domain_scores_codex":[0.9998362,0.00002089089,0.00001036492,0.00003931278,0.00006629969,0.00002697168],"domain_scores_gemma":[0.999872,0.00003267321,0.00003107772,0.00002289586,0.00001561224,0.00002577665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003750796,0.00001064423,0.0002933755,0.00001081983,0.000002077059,0.00004414488,0.00001331381,0.0003146832,0.9979829,0.0002119927,0.00001452205,0.001064152],"study_design_scores_gemma":[0.0000262955,0.0002167092,0.005460479,0.000004797927,0.00001166514,0.0003303209,0.00006029671,0.02541105,0.9671089,0.0004180431,0.000927915,0.00002355949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946386,0.0002785032,0.004369972,0.00009066232,0.00001124554,0.000006284288,0.00002166175,0.0001716876,0.0004114125],"genre_scores_gemma":[0.9980403,0.0001208769,0.001447682,0.0000166814,0.000003154976,0.000005940024,0.0000166609,0.00001069738,0.0003380198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620415,"threshold_uncertainty_score":0.003741145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002103177075536032,"score_gpt":0.1891612311463514,"score_spread":0.1870580540708154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}