{"id":"W4391686029","doi":"10.1002/exp.20230008","title":"Cornea‐SELEX for aptamers targeting the surface of eyes and liposomal drug delivery","year":2024,"lang":"en","type":"article","venue":"Exploration","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Liposome; Drug delivery; Cornea; Targeted drug delivery; Drug; Nanotechnology; Medicine; Chemistry; Ophthalmology; Biology; Pharmacology; Materials science; Molecular biology; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128928,0.0004477965,0.0002978608,0.000199249,0.0001568467,0.0004086134,0.0001790111,0.0003107112,0.001519817],"category_scores_gemma":[0.0002122623,0.0001847446,0.0002637242,0.0001329689,0.0001982625,0.0001920892,0.0003468253,0.0003491314,0.0006302494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002545522,"about_ca_system_score_gemma":0.0002184202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002870229,"about_ca_topic_score_gemma":0.0004618369,"domain_scores_codex":[0.9998322,0.00003202519,0.00001684827,0.00004030628,0.00005179605,0.00002689164],"domain_scores_gemma":[0.9999101,0.00002480513,0.00002419067,0.00001118266,0.00001753148,0.00001220601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003339482,0.00001890561,0.0001466252,0.00003069233,0.000006597419,0.00004696879,0.00001609774,0.0003116353,0.9959133,0.000086837,0.0000885081,0.003300377],"study_design_scores_gemma":[0.000005831578,0.0000722578,0.0002695804,0.000002464228,0.000006197574,0.00009497249,0.000007821673,0.00117812,0.9964534,0.0000198827,0.001885949,0.000003583479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9164132,0.001724374,0.07578322,0.000198142,0.00006497238,0.0003647477,0.0006912421,0.0004560076,0.004304136],"genre_scores_gemma":[0.9413853,0.001184224,0.04416779,0.0002018288,0.00001076213,0.0002555077,0.0007364415,0.0001495632,0.01190852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001519817,"threshold_uncertainty_score":0.005084336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294102103225852,"score_gpt":0.2669268817677994,"score_spread":0.2539858607355409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}