{"id":"W4391686029","doi":"10.1002/exp.20230008","title":"Cornea‐SELEX for aptamers targeting the surface of eyes and liposomal drug delivery","year":2024,"lang":"en","type":"article","venue":"Exploration","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; Systematic evolution of ligands by exponential enrichment; Liposome; Drug delivery; Cornea; Targeted drug delivery; Drug; Nanotechnology; Medicine; Chemistry; Ophthalmology; Biology; Pharmacology; Materials science; Molecular biology; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783211,0.00006419914,0.00006313503,0.00001486378,0.00005989454,0.00002447759,0.0000385307,0.0000398806,3.039511e-7],"category_scores_gemma":[0.00003438618,0.00004438322,0.00004657648,0.00006007788,0.00006010161,0.000009486499,0.00002357009,0.00003067661,3.526895e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004249455,"about_ca_system_score_gemma":0.00001725313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007106601,"about_ca_topic_score_gemma":0.00001709901,"domain_scores_codex":[0.999581,0.00002472273,0.0001118186,0.0001569164,0.00004895336,0.00007659337],"domain_scores_gemma":[0.9997715,0.00002503933,0.0000396107,0.00008588204,0.0000643652,0.00001357858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002795762,0.000006485861,0.0000620974,0.00002339367,0.0000302148,2.266925e-7,0.0001232864,0.00003551331,0.9892775,0.0000981732,0.002680068,0.007635129],"study_design_scores_gemma":[0.00005203807,0.00007899462,0.00001725035,0.00001873085,0.00002737881,0.0000010378,0.0004604063,0.003572413,0.9833224,0.0003547912,0.01202482,0.00006975447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823688,0.001889378,0.01485558,0.0005932818,0.00006682672,0.0001413177,0.00001548265,0.00003087749,0.00003848701],"genre_scores_gemma":[0.9930722,0.0007033849,0.005789658,0.00004466185,0.0001158078,0.00000619131,0.0001137353,0.000008903703,0.0001454448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01070344,"threshold_uncertainty_score":0.1809895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294102103225852,"score_gpt":0.2669268817677994,"score_spread":0.2539858607355409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}