{"id":"W4391690732","doi":"10.3389/fcell.2024.1256465","title":"Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cranial neural crest; Cell biology; Craniofacial; Neural crest; Ectoderm; Anatomy; Mesenchyme; Mesoderm; Embryonic stem cell; Embryogenesis; Genetics; Embryo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054401,0.0005024608,0.0002546854,0.0005551388,0.0001650772,0.000262913,0.0002910558,0.0004247105,0.001763141],"category_scores_gemma":[0.0001012957,0.0002593088,0.000201467,0.0001628021,0.0003305609,0.0001507963,0.0002648341,0.000618923,0.0004406233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003788256,"about_ca_system_score_gemma":0.0002210209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005237201,"about_ca_topic_score_gemma":0.0008250971,"domain_scores_codex":[0.999837,0.00002331003,0.00001887149,0.00003944862,0.00005380009,0.00002755962],"domain_scores_gemma":[0.9998591,0.00002161468,0.00005337684,0.00001348545,0.000006160313,0.00004619517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005963804,0.00001689151,0.0001319535,0.00001122184,0.000003418767,0.00008430034,0.00000559884,0.00005254312,0.9990562,0.00006698184,0.00001174112,0.000499426],"study_design_scores_gemma":[0.0000281278,0.0002314502,0.0196441,0.000008114192,0.00003640137,0.000831098,0.00003753163,0.001163632,0.974326,0.0001057679,0.003579762,0.000008116157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953335,0.000906796,0.00143166,0.00006199326,0.00002230496,0.00002146496,0.0004711323,0.0001045257,0.001646552],"genre_scores_gemma":[0.9929026,0.0006734996,0.001051245,0.00004280368,0.000005437043,0.00003165605,0.0004885499,0.00004849562,0.004755666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763141,"threshold_uncertainty_score":0.005898297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008559922973751532,"score_gpt":0.2329472379814893,"score_spread":0.2243873150077378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}