{"id":"W4391691223","doi":"10.1016/j.bone.2024.117043","title":"Epigenetic regulators controlling osteogenic lineage commitment and bone formation","year":2024,"lang":"en","type":"review","venue":"Bone","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; CancerCare Manitoba Foundation; Erasmus Universitair Medisch Centrum Rotterdam; Erasmus Medisch Centrum; Harvard University","keywords":"Biology; Epigenetics; Epigenetic regulation of neurogenesis; Cell biology; Histone; Regulation of gene expression; Chromatin; Chromatin remodeling; Cellular differentiation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981436,0.0005026598,0.0005171615,0.0007703431,0.000173108,0.0006598998,0.0003717212,0.0004374278,0.004257352],"category_scores_gemma":[0.0002787011,0.0001528721,0.0003061249,0.0005665495,0.0001899502,0.0006171336,0.0004073395,0.0005636745,0.001363466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004046253,"about_ca_system_score_gemma":0.0006884541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00059299,"about_ca_topic_score_gemma":0.001273611,"domain_scores_codex":[0.9998868,0.0000128004,0.00001718438,0.00002425932,0.00004303437,0.00001594109],"domain_scores_gemma":[0.9999346,0.00001994722,0.00001758541,0.000002028335,0.00001954453,0.000006325647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001634842,0.00003771486,0.0008550837,0.02442972,0.0001577138,0.0009527756,0.0003710149,0.0009600277,0.0761983,0.01577621,0.03243225,0.8476657],"study_design_scores_gemma":[0.000006912211,0.00008557819,0.001730339,0.001324005,0.00009803142,0.001284575,0.00009915672,0.0001594158,0.009234916,0.001922913,0.9840321,0.00002203219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002723957,0.9878744,0.001582448,0.0006391059,0.0005505403,0.00002126106,0.0002419781,0.00004970434,0.006316564],"genre_scores_gemma":[0.01018998,0.9833112,0.0009344037,0.0003053259,0.0004199221,0.00002441118,0.0003094507,0.000007774584,0.004497587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004257352,"threshold_uncertainty_score":0.01424223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807728128390632,"score_gpt":0.2888811724719872,"score_spread":0.2708038911880809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}