{"id":"W4391692411","doi":"10.1101/2024.02.08.579178","title":"Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; Alfred P. Sloan Foundation; National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Alzheimer's Association","keywords":"Microglia; Synapse; Neuroscience; CX3CR1; Astrocyte; Crosstalk; Biology; CX3CL1; Cell biology; Central nervous system; Immune system; Chemokine; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001394679,0.0004334623,0.0003714748,0.0003934053,0.0003387325,0.0008498504,0.0001612531,0.0004362735,0.001178953],"category_scores_gemma":[0.0001855958,0.0002752536,0.0004386868,0.0002238238,0.0003952378,0.0003906273,0.0004829045,0.0008274955,0.0006616808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004684104,"about_ca_system_score_gemma":0.0005086191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350292,"about_ca_topic_score_gemma":0.003515998,"domain_scores_codex":[0.9996262,0.00004406333,0.00002798556,0.00005293897,0.0001224679,0.0001263106],"domain_scores_gemma":[0.9998546,0.000008632012,0.00006055136,0.0000110388,0.00002396378,0.00004121101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516482,0.0000142607,0.0007010793,0.00004417344,0.000009953616,0.0001308062,0.00003791222,0.00008385804,0.9970098,0.0003235025,0.00009253884,0.001400524],"study_design_scores_gemma":[0.00004124161,0.0001482784,0.03530229,0.00003452905,0.00004474886,0.0004745615,0.0002137006,0.001929089,0.9573394,0.0004692397,0.003991001,0.00001196689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843834,0.00403707,0.005970538,0.0004159012,0.00006831381,0.00003060781,0.0007032463,0.0002329507,0.004158001],"genre_scores_gemma":[0.9914262,0.002092672,0.002525793,0.00009391351,0.00001463528,0.0000418882,0.0003109142,0.00005622349,0.003437755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350292,"threshold_uncertainty_score":0.00394398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175915063078192,"score_gpt":0.2314328519365066,"score_spread":0.2096737013057247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}