{"id":"W4391707159","doi":"10.1097/med.0000000000000857","title":"APOC3 siRNA and ASO therapy for dyslipidemia","year":2024,"lang":"en","type":"article","venue":"Current Opinion in Endocrinology Diabetes and Obesity","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal","funders":"","keywords":"Hypertriglyceridemia; Medicine; Fatty liver; Dyslipidemia; Triglyceride; Pharmacology; Internal medicine; Endocrinology; Cholesterol; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370866,0.0001615216,0.0003365517,0.0001612619,0.00006229668,0.00002604826,0.00004668811,0.00007752862,0.0000219568],"category_scores_gemma":[0.00008258057,0.0001289457,0.00006462194,0.0001102716,0.0001481181,0.0000908613,0.00005351757,0.0002191851,0.000005376681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001310999,"about_ca_system_score_gemma":0.00004158959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005619606,"about_ca_topic_score_gemma":0.000001359997,"domain_scores_codex":[0.9989243,0.00003837805,0.0002100248,0.0003776205,0.00006782373,0.0003818605],"domain_scores_gemma":[0.9994977,0.0002109835,0.00002580821,0.0001356595,0.00002724659,0.000102656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004809755,0.0001581808,0.7392598,0.001124125,0.00004395147,7.072151e-7,0.0002081758,4.505448e-7,0.0002458563,0.01078958,0.00546944,0.2426516],"study_design_scores_gemma":[0.002793238,0.0002369758,0.5437186,0.0003012723,0.00003695489,0.00000702123,0.00009057495,0.000676345,0.0003990703,0.00437062,0.4471754,0.0001939335],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8371996,0.1567678,0.00006628664,0.001115029,0.004198047,0.0004652356,0.00002370855,0.00006997615,0.00009433064],"genre_scores_gemma":[0.9520245,0.04658029,0.0001890277,0.0002234554,0.0007119867,0.0001221174,0.00007161785,0.00002003674,0.00005694831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4417059,"threshold_uncertainty_score":0.5258255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03799794778896185,"score_gpt":0.3433846099786834,"score_spread":0.3053866621897215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}