{"id":"W4391713937","doi":"10.1093/jcag/gwae005","title":"Impact of CYP2C19 metabolizer status on esophageal mucosal inflammation, acid exposure, and motility among patients on chronic proton-pump inhibitor therapy with refractory symptoms of gastroesophageal reflux disease","year":2024,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research; Schulich School of Medicine and Dentistry, Western University; Academic Medical Organization of Southwestern Ontario","keywords":"Gastroenterology; Medicine; Internal medicine; CYP2C19; GERD; Reflux; Proton-pump inhibitor; Refractory (planetary science); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004250353,0.0002169512,0.0003963342,0.0006361827,0.000366374,0.0003694966,0.0001354829,0.0002845228,0.001330391],"category_scores_gemma":[0.001323424,0.0001283054,0.0003343669,0.0006327768,0.0002098755,0.0003221618,0.0002843617,0.000236987,0.0001352989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295467,"about_ca_system_score_gemma":0.0001407732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008760928,"about_ca_topic_score_gemma":0.001185322,"domain_scores_codex":[0.9995253,0.0001539707,0.00007409063,0.00009575448,0.00008154992,0.00006938903],"domain_scores_gemma":[0.9988575,0.000252389,0.0005597516,0.00005496642,0.00007292076,0.0002024723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001047513,0.00001281558,0.9992216,0.000003382576,0.00001916886,0.00006504104,0.00001077247,0.000007678671,0.0001178012,0.000002566831,0.00001200673,0.0004224466],"study_design_scores_gemma":[0.000004699215,0.0001417078,0.9992374,0.000002312138,0.00002029104,0.000379263,0.00006150347,0.00006031906,0.00004395736,0.000004760838,0.00004270403,0.000001066204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994313,0.0002678882,0.00002893731,0.00001121684,0.0000020462,0.000003612752,0.00006621289,7.015485e-7,0.000187993],"genre_scores_gemma":[0.9998068,0.00005344821,0.00002499071,0.00000911298,0.000006538274,0.00000223344,0.00006907484,4.435688e-7,0.00002745446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330391,"threshold_uncertainty_score":0.004450679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600802790752557,"score_gpt":0.245351393320662,"score_spread":0.2397505905299094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}