{"id":"W4391722169","doi":"10.1038/s41419-024-06523-x","title":"CHCHD2 up-regulation in Huntington disease mediates a compensatory protective response against oxidative stress","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"Oxidative stress; Biology; Gene knockdown; Huntington's disease; Cell biology; Oxidative phosphorylation; Phenotype; Mitochondrion; Induced pluripotent stem cell; Apoptosis; Cell; Gene; Disease; Genetics; Endocrinology; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001672412,0.0002931746,0.0001812973,0.0002777088,0.0001724806,0.0001996038,0.0001617829,0.00003850335,0.00004588153],"category_scores_gemma":[0.001722105,0.0002740114,0.00008829013,0.0003587267,0.0001938296,0.0002726073,0.0001219773,0.0001677988,0.00005531125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006647831,"about_ca_system_score_gemma":0.0004731671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008038627,"about_ca_topic_score_gemma":0.000004194683,"domain_scores_codex":[0.9974321,0.0006725647,0.000251189,0.0009247513,0.0003530877,0.0003662895],"domain_scores_gemma":[0.9981732,0.000535952,0.00006294022,0.00031065,0.00004874579,0.0008685463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005330199,0.0006684585,0.04063289,0.0007207103,0.000009372206,0.0004452059,0.001433371,0.001328421,0.9458856,0.001330629,0.0002867743,0.001928349],"study_design_scores_gemma":[0.0008187732,0.00007073989,0.3689066,0.0002009944,0.00005755807,2.831245e-7,0.0001351391,0.009833639,0.6167973,0.002533941,0.0002437044,0.0004014088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964264,0.001082502,0.0001131465,0.0002773317,0.0002547528,0.0009774093,0.0004857969,0.0001435217,0.0002391548],"genre_scores_gemma":[0.9985734,0.00006207781,0.0000181908,0.0006239957,0.00007819942,0.0002464371,0.00003938761,0.00004074659,0.0003175708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3290884,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921659144924337,"score_gpt":0.2564112891082169,"score_spread":0.2371946976589735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}