{"id":"W4391722392","doi":"10.1002/ajh.27243","title":"Donor germ‐line variants associate with outcomes of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndromes","year":2024,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Moonshot; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; U.S. Navy; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Astellas Pharma; Adaptive Biotechnologies; Norges Idrettshøgskole; Kiadis Pharma; bluebird bio; TG Therapeutics; Jazz Pharmaceuticals; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; StemCyte; BeiGene; HistoGenetics; U.S. Department of Defense; Moonshot Research and Development Program; Sanofi; GlaxoSmithKline; Actinium Pharmaceuticals; CareDx; Incyte; Pfizer; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Amgen; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Atara Biotherapeutics; National Cancer Institute; Gilead Sciences","keywords":"Myelodysplastic syndromes; Stem cell; Medicine; Hematopoietic stem cell transplantation; Transplantation; Oncology; Germline; Hematopoietic cell; Haematopoiesis; Internal medicine; Biology; Genetics; Bone marrow; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001878117,0.0001660036,0.0002888165,0.000249282,0.0003364822,0.0002762582,0.0001929672,0.0008225769,0.002894366],"category_scores_gemma":[0.001328736,0.00009975018,0.0001871141,0.0004818506,0.0001811422,0.0001482765,0.0001244879,0.0005637747,0.000362349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220053,"about_ca_system_score_gemma":0.0001823831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693208,"about_ca_topic_score_gemma":0.002323816,"domain_scores_codex":[0.9998654,0.00003849695,0.0000118743,0.00003206171,0.00002102957,0.00003111643],"domain_scores_gemma":[0.9993153,0.0002754313,0.0001466133,0.00003998566,0.00006440229,0.000158182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001070689,0.00004685551,0.975648,0.00001948458,0.00006885442,0.004557017,0.0001205914,0.0002980359,0.001555915,0.0001959388,0.009104808,0.007313763],"study_design_scores_gemma":[0.0001294318,0.000267643,0.9745854,0.00003229658,0.0001025518,0.01671086,0.0003007493,0.001797359,0.0004893696,0.001056007,0.004506072,0.00002235099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913256,0.0004122611,0.00009523777,0.004307076,0.0001703004,0.000004903839,0.0008031689,0.00001286313,0.002868652],"genre_scores_gemma":[0.9974523,0.0001223193,0.00006074047,0.001015379,0.0002078377,0.000005122409,0.0003116133,0.000002937258,0.0008216865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002894366,"threshold_uncertainty_score":0.009682655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009485209127532675,"score_gpt":0.252964729885824,"score_spread":0.2434795207582913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}