{"id":"W4391729395","doi":"10.1101/2024.02.05.579017","title":"Senolytic treatment depletes microglia and decreases severity of experimental autoimmune encephalomyelitis","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Experimental autoimmune encephalomyelitis; Neurodegeneration; Inflammation; Multiple sclerosis; Senescence; Encephalomyelitis; Immunology; Biology; Neuroprotection; Medicine; Neuroscience; Disease; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655454,0.0004654406,0.0004458718,0.0003456102,0.0001560989,0.0002282924,0.0001920939,0.0002446763,0.002477042],"category_scores_gemma":[0.00007956709,0.000132773,0.0002417124,0.0001131441,0.0001794699,0.0001206844,0.0001638534,0.0006742981,0.0005016398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001077305,"about_ca_system_score_gemma":0.0002066387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003744026,"about_ca_topic_score_gemma":0.0009961809,"domain_scores_codex":[0.9998956,0.00002028371,0.00001348161,0.00001470411,0.00002615612,0.0000299125],"domain_scores_gemma":[0.9999168,0.000008461981,0.0000212138,0.000009555408,0.00001120905,0.00003280901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005230843,0.0001630139,0.0001210063,0.00006087692,0.00001272397,0.00002037821,0.000008532387,0.00006161162,0.9962697,0.00003031906,0.00009979554,0.002629043],"study_design_scores_gemma":[0.0001566349,0.00430213,0.009656199,0.00003919067,0.00005911653,0.0002042912,0.00004836238,0.0007588053,0.9808521,0.0000840665,0.003829248,0.000009763278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920631,0.003218201,0.001392481,0.0001735571,0.00007332264,0.00007684236,0.0006978826,0.0002898946,0.002014603],"genre_scores_gemma":[0.9888901,0.003198329,0.002357124,0.0002537003,0.00004408785,0.0001300188,0.001010167,0.00005704293,0.004059472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477042,"threshold_uncertainty_score":0.008286536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201989592739842,"score_gpt":0.239892090948263,"score_spread":0.2178721950208646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}