{"id":"W4391738614","doi":"10.1186/s13075-023-03257-7","title":"Long-term safety of Ixekizumab in adults with psoriasis, psoriatic arthritis, or axial spondyloarthritis: a post-hoc analysis of final safety data from 25 randomized clinical trials","year":2024,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto; Memorial University of Newfoundland","funders":"Eli Lilly and Company","keywords":"Medicine; Psoriatic arthritis; Ixekizumab; Adverse effect; Psoriasis; Internal medicine; Ankylosing spondylitis; Randomized controlled trial; Axial spondyloarthritis; Incidence (geometry); Rheumatology; Arthritis; Dermatology; Secukinumab; Sacroiliitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01916256,0.0006786789,0.006539313,0.001761702,0.0002448951,0.0001364623,0.0007995042,0.0004316484,0.003901708],"category_scores_gemma":[0.006161764,0.0004816395,0.001340564,0.003736364,0.001693356,0.0005205462,0.0004093532,0.001196812,0.00005572409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001867008,"about_ca_system_score_gemma":0.001442418,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003185618,"about_ca_topic_score_gemma":0.02899305,"domain_scores_codex":[0.9832114,0.006699362,0.004706232,0.001846786,0.002353453,0.001182775],"domain_scores_gemma":[0.9813729,0.01427146,0.0006159953,0.002242558,0.001024043,0.0004730201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4339234,0.00137748,0.005585944,0.0001126627,0.008732695,0.002574404,0.001009695,0.000002658957,0.00005025132,0.0001965854,0.0002512812,0.546183],"study_design_scores_gemma":[0.824302,0.01620644,0.1284572,0.01986547,0.002093826,0.0002207746,0.001480152,0.001201702,0.000202375,0.0003910503,0.004715716,0.0008632407],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7871984,0.1993544,0.0001836714,0.001048433,0.0005334949,0.004639285,0.006720731,0.00008720946,0.0002343407],"genre_scores_gemma":[0.6028435,0.3923784,0.0007554216,0.00006256864,0.0004276721,0.0002757606,0.003081681,0.00007321586,0.0001017707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5453197,"threshold_uncertainty_score":0.9997635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1364374593781157,"score_gpt":0.4476774028224897,"score_spread":0.311239943444374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}