{"id":"W4391745281","doi":"10.1016/j.celrep.2024.113773","title":"THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Université de Bordeaux; Fondation ARC pour la Recherche sur le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Myeloid; Hepatocellular carcinoma; Immunology; Inflammation; Cancer research; Immunotherapy; Immunosuppression; Biology; Immune system; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220608,0.000194439,0.0001423745,0.0004429729,0.0001225953,0.0001955496,0.00006401609,0.0001177667,0.003075686],"category_scores_gemma":[0.0001179969,0.00009121289,0.0000977469,0.0001378093,0.0001402625,0.000169962,0.000183286,0.0003605627,0.0005180283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223131,"about_ca_system_score_gemma":0.0001298666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390218,"about_ca_topic_score_gemma":0.0002848621,"domain_scores_codex":[0.9999107,0.00002457913,0.000007615915,0.00001117915,0.00002015285,0.00002576421],"domain_scores_gemma":[0.9998912,0.00001043748,0.0000405511,0.000008463468,0.00001198096,0.00003734478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001090715,0.00009748719,0.03261564,0.0001382281,0.00001730612,0.000690781,0.00008683203,0.00009020332,0.9540328,0.0004862405,0.0003769395,0.01027689],"study_design_scores_gemma":[0.0002184081,0.002079668,0.4004396,0.00005905941,0.0001689418,0.008231482,0.0006014155,0.003457962,0.5636978,0.001236955,0.01978601,0.00002269669],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961196,0.001224793,0.0009938463,0.0001110758,0.00001401616,0.00002872421,0.0001780499,0.00003360405,0.001296291],"genre_scores_gemma":[0.9971667,0.0004154678,0.0005557618,0.00004322928,0.00002618678,0.00002338854,0.0002215009,0.00000518958,0.001542651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003075686,"threshold_uncertainty_score":0.01028919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01036021454846457,"score_gpt":0.2136833977225414,"score_spread":0.2033231831740769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}