{"id":"W4391750585","doi":"10.1016/j.ebiom.2024.105010","title":"Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"Department of Epidemiology and Biostatistics, University of California, San Francisco; Department of Pathology, Northwestern University; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; Ontario Ministry of Research and Innovation; School of Public Health, Imperial College London; Medical Research Council; Vetenskapsrådet; University of Maryland School of Public Health; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; National Institutes of Health; Umeå Universitet; Hjärnfonden; Ontario Ministry of Research, Innovation and Science; Västerbotten Läns Landsting; University Hospitals Bristol NHS Foundation Trust; Canadian Institutes of Health Research; Cancerfonden; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; University of Bristol; Imperial College London; Centre International de Recherche sur le Cancer; NIHR Bristol Biomedical Research Centre; Johns Hopkins University; Canadian Cancer Society; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; Government of South Australia; Cancer Council Victoria; Australian Lions Childhood Cancer Research Foundation; Marshfield Clinic Research Foundation; NIHR Imperial Biomedical Research Centre; Ontario Research Foundation; Lung Cancer Research Foundation; Prevent Cancer Foundation; Victorian Cancer Agency; American Cancer Society; VicHealth; Brigham and Women's Hospital; Emory University; Fred Hutchinson Cancer Research Center; World Health Organization; Cancer Research UK; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Randomization; Biology; Genetics; Medicine; Oncology; Bioinformatics; Internal medicine; Cancer; Gene; Clinical trial; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02865559,0.001630219,0.002152868,0.001993452,0.0006817108,0.001098596,0.001409263,0.001661594,0.006625412],"category_scores_gemma":[0.03834376,0.0008482298,0.004760122,0.001561995,0.001180263,0.0007328469,0.001080643,0.001196421,0.000339428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000574564,"about_ca_system_score_gemma":0.000953079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003696874,"about_ca_topic_score_gemma":0.001655904,"domain_scores_codex":[0.9649056,0.02833006,0.0009175609,0.003689077,0.001281701,0.0008760351],"domain_scores_gemma":[0.9644392,0.02456035,0.003983136,0.005864865,0.0005981104,0.0005544218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1123547,0.001270769,0.6394646,0.001359305,0.08861094,0.004664082,0.001214686,0.03025225,0.01722211,0.02534246,0.005033091,0.07321107],"study_design_scores_gemma":[0.01906914,0.0157179,0.4105621,0.0003108651,0.05299464,0.007050517,0.0006529558,0.4368066,0.006508855,0.04113161,0.008677332,0.0005175063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8828023,0.001805398,0.1103673,0.0005461419,0.0001535706,0.0009699587,0.001651721,0.0005262584,0.001177542],"genre_scores_gemma":[0.9602001,0.0003510075,0.03673719,0.0001784052,0.000061304,0.001018985,0.0004625993,0.00008293339,0.0009073655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02865559,"threshold_uncertainty_score":0.1515471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664070232772572,"score_gpt":0.3001936279420281,"score_spread":0.2835529256143023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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