{"id":"W4391750585","doi":"10.1016/j.ebiom.2024.105010","title":"Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"Department of Epidemiology and Biostatistics, University of California, San Francisco; Department of Pathology, Northwestern University; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; Ontario Ministry of Research and Innovation; School of Public Health, Imperial College London; Medical Research Council; Vetenskapsrådet; University of Maryland School of Public Health; National Institute of General Medical Sciences; Centers for Disease Control and Prevention; National Institutes of Health; Umeå Universitet; Hjärnfonden; Ontario Ministry of Research, Innovation and Science; Västerbotten Läns Landsting; University Hospitals Bristol NHS Foundation Trust; Canadian Institutes of Health Research; Cancerfonden; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; University of Bristol; Imperial College London; Centre International de Recherche sur le Cancer; NIHR Bristol Biomedical Research Centre; Johns Hopkins University; Canadian Cancer Society; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; Government of South Australia; Cancer Council Victoria; Australian Lions Childhood Cancer Research Foundation; Marshfield Clinic Research Foundation; NIHR Imperial Biomedical Research Centre; Ontario Research Foundation; Lung Cancer Research Foundation; Prevent Cancer Foundation; Victorian Cancer Agency; American Cancer Society; VicHealth; Brigham and Women's Hospital; Emory University; Fred Hutchinson Cancer Research Center; World Health Organization; Cancer Research UK; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Colorectal cancer; Randomization; Biology; Genetics; Medicine; Oncology; Bioinformatics; Internal medicine; Cancer; Gene; Clinical trial; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002714811,0.0001311735,0.0003613789,0.0002175668,0.00004374403,0.00001435137,0.00002114566,0.00007380037,0.00006640264],"category_scores_gemma":[0.0003085706,0.00009511583,0.00005242322,0.0004904261,0.0001420469,0.00004630334,0.0000223517,0.0001260126,9.554464e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000400778,"about_ca_system_score_gemma":0.00007692687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108136,"about_ca_topic_score_gemma":0.00008885516,"domain_scores_codex":[0.9991174,0.00004917173,0.0002373449,0.000262479,0.0002083482,0.0001252694],"domain_scores_gemma":[0.999438,0.000215708,0.00006794031,0.00008861868,0.00008063491,0.0001090448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009752404,0.00004920151,0.01715403,0.0005981665,0.0008739716,0.00009219566,0.001037556,0.00002628558,0.9158453,0.00009119921,0.0004312294,0.0540484],"study_design_scores_gemma":[0.02785627,0.01129789,0.3589548,0.002391542,0.006283539,0.00046761,0.000814435,0.05439087,0.5329187,0.001021054,0.002968248,0.0006350648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732372,0.02362896,0.001593614,0.00055836,0.0002193374,0.0002579928,0.00002931605,0.00009209893,0.0003831075],"genre_scores_gemma":[0.9958844,0.003280468,0.0005054112,0.00005617163,0.0001243086,0.00002782704,0.00001865014,0.00001754718,0.0000852242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3829266,"threshold_uncertainty_score":0.3878711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664070232772572,"score_gpt":0.3001936279420281,"score_spread":0.2835529256143023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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