{"id":"W4391752069","doi":"10.1016/j.abb.2024.109924","title":"Interrogating l-fuconate dehydratase with tartronate and 3-hydroxypyruvate reveals subtle differences within the mandelate racemase-subgroup of the enolase superfamily","year":2024,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dehydratase; Chemistry; Stereochemistry; Active site; Enzyme; Enolase; Catalysis; Circular dichroism; Bifunctional; Enol; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188774,0.0001477439,0.0001621523,0.00001463508,0.000131339,0.00005311596,0.0001582323,0.0000354825,0.00000642325],"category_scores_gemma":[0.00001760263,0.00007166916,0.00004260205,0.00009931331,0.0007388821,0.00009127236,0.000136003,0.0001440566,5.513211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002880763,"about_ca_system_score_gemma":0.00002931172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004154039,"about_ca_topic_score_gemma":0.00001154149,"domain_scores_codex":[0.9992395,0.00004520652,0.0002094826,0.000250686,0.0001283819,0.000126736],"domain_scores_gemma":[0.9994386,0.0001651761,0.0001258678,0.0002187644,0.00001556947,0.0000360163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008347619,0.00001205445,0.0006237144,0.0003376226,0.0000239504,0.000002592657,0.001461548,0.00001161112,0.9961208,0.0006780268,0.000007801013,0.0006368455],"study_design_scores_gemma":[0.0001725982,0.00009030242,0.001381746,0.000355451,0.0000602177,0.00001799178,0.0006286587,0.001000055,0.9905686,0.005614097,0.000008279859,0.0001019957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984104,0.0007385096,0.00007035538,0.000156546,0.00009138968,0.00009638462,0.0001455199,0.0000156736,0.0002752147],"genre_scores_gemma":[0.9994109,0.00006165318,0.0002875635,0.00003159894,0.00005053495,0.000004828904,0.00001190669,0.00000834271,0.0001327249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00555215,"threshold_uncertainty_score":0.2922583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005048628956458207,"score_gpt":0.1869471047277711,"score_spread":0.1818984757713129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}