{"id":"W4391752237","doi":"10.3390/axioms13020117","title":"Estimating the Rate of Mutation to a Mutator Phenotype","year":2024,"lang":"en","type":"article","venue":"Axioms","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Society for the Study of Evolution; National Institutes of Health; National Science Foundation","keywords":"Mutation rate; Mutation; Biology; Mutation Accumulation; Population; Genetics; Mutant; Natural selection; Phenotype; Evolutionary biology; Rate of evolution; Neutral mutation; Gene; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345407,0.0000472053,0.00003911322,0.00001813429,0.0000274313,0.00001488582,0.00007067181,0.00003042209,0.00001302587],"category_scores_gemma":[0.00006590461,0.00003439841,0.00003049874,0.000102773,0.00002874163,9.985953e-7,0.00003254168,0.00002678838,0.00003553732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004402342,"about_ca_system_score_gemma":0.00003847115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001833223,"about_ca_topic_score_gemma":0.0000179563,"domain_scores_codex":[0.9996508,0.00002228823,0.00009656714,0.000115529,0.00004092506,0.00007390379],"domain_scores_gemma":[0.999786,0.00001110939,0.00001690841,0.0001285089,0.00003334763,0.00002408041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003592949,0.00002447917,0.0000361593,0.00005820871,0.0000771283,0.000005340333,0.0008929515,0.02315255,0.9236499,0.007059303,0.002915179,0.04209286],"study_design_scores_gemma":[0.0004632346,0.0007213281,0.00752329,0.0001129589,0.00008518037,0.00005013946,0.0004965521,0.7619721,0.2013379,0.002855435,0.02394944,0.0004324935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7051036,0.0004379014,0.2930061,0.0005569743,0.0002703216,0.00009017588,0.000007967676,0.00001166226,0.0005152437],"genre_scores_gemma":[0.997113,0.000003939262,0.001870029,0.0002848389,0.0001062364,0.000007622652,0.0000275504,0.000008868904,0.000577947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7388195,"threshold_uncertainty_score":0.1402727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005906949957994053,"score_gpt":0.2676581491133133,"score_spread":0.2617511991553192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}