{"id":"W4391754110","doi":"10.1101/2024.02.11.579846","title":"Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Heart, Lung, and Blood Institute","keywords":"Glycolysis; Pulmonary hypertension; Fatty acid; Biochemistry; Chemistry; Cardiology; Internal medicine; Cell biology; Biology; Medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101184,0.0001735936,0.0002322167,0.0002400079,0.000190191,0.0002838809,0.0001412499,0.0002446987,0.0008483616],"category_scores_gemma":[0.0001106246,0.0001260222,0.0002814874,0.0002194454,0.0001550928,0.0001781996,0.0002023755,0.0003541925,0.0002763649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001921546,"about_ca_system_score_gemma":0.0001627803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000974664,"about_ca_topic_score_gemma":0.001696179,"domain_scores_codex":[0.9998947,0.000005623932,0.000004573663,0.0000452362,0.00002561084,0.00002421684],"domain_scores_gemma":[0.9999338,0.00001078294,0.00001838939,0.000007439679,0.00001605976,0.00001349446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109663,0.000006032236,0.00202583,0.00005114893,0.00001151905,0.00004211033,0.00001873942,0.000153254,0.995654,0.00006578033,0.00008091073,0.001780962],"study_design_scores_gemma":[0.00003535647,0.0002847918,0.3907629,0.0000492489,0.00016462,0.0008259793,0.0004095593,0.01258093,0.5872726,0.0007577306,0.006818831,0.00003741945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807292,0.001434003,0.01180819,0.000105732,0.00003667346,0.00002000423,0.00492922,0.0001369251,0.0008001886],"genre_scores_gemma":[0.9870517,0.000773415,0.005668801,0.000124771,0.00001306644,0.00004706941,0.00382971,0.00004407948,0.002447323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000974664,"threshold_uncertainty_score":0.002838016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022325681640344,"score_gpt":0.230917077450562,"score_spread":0.208591395810218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}