{"id":"W4391756221","doi":"10.1101/2024.02.08.578867","title":"MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Sahlgrenska Akademin; Vetenskapsrådet; Science for Life Laboratory; Åke Wiberg Stiftelse; CH.I.L.D. Foundation; Uppsala Multidisciplinary Center for Advanced Computational Science; Stiftelsen Clas Groschinskys Minnesfond; Svenska Sällskapet för Medicinsk Forskning; Knut och Alice Wallenbergs Stiftelse; National Institutes of Health; Sahlgrenska Universitetssjukhuset; Jeanssons Stiftelser; Wenner-Gren Stiftelserna","keywords":"Glycocalyx; Component (thermodynamics); Crohn's disease; Disease; Biology; Cell biology; Medicine; Physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247635,0.0003915779,0.0003027903,0.0004545091,0.0002273755,0.0003600302,0.00020801,0.0004717516,0.004899276],"category_scores_gemma":[0.0002535105,0.0001910824,0.0002388428,0.000292591,0.0002083443,0.0002111988,0.0003015403,0.0005032037,0.002116798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845774,"about_ca_system_score_gemma":0.0002289904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004574476,"about_ca_topic_score_gemma":0.0003135145,"domain_scores_codex":[0.9998838,0.00001411829,0.00001076828,0.00001960649,0.00005220639,0.00001955344],"domain_scores_gemma":[0.9998624,0.00001639072,0.00003747224,0.00001781155,0.00002549504,0.00004041331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006300117,0.00002763919,0.004181702,0.0002045583,0.00003367015,0.0009990399,0.00004534817,0.0001738726,0.9796926,0.0006586084,0.003832856,0.009520167],"study_design_scores_gemma":[0.0001055991,0.0002331009,0.05693602,0.00008223394,0.0001069269,0.007434221,0.0001475037,0.002430222,0.8791592,0.001522076,0.05181877,0.00002409449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695746,0.009263084,0.007128915,0.0024122,0.0009832053,0.00003236166,0.00439642,0.0006711227,0.005538133],"genre_scores_gemma":[0.9689296,0.003838498,0.005430811,0.0002852346,0.0001940144,0.00002687271,0.005818299,0.0002545472,0.01522216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004899276,"threshold_uncertainty_score":0.01638967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373327572048901,"score_gpt":0.2680272220566742,"score_spread":0.2442939463361852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}