{"id":"W4391771587","doi":"10.1101/2024.02.11.24302594","title":"A Phase II Study Integrating a Single-Blind Safety Phase with a Double-Blind, Placebo-Controlled Randomized Phase, Assessing Single-Dose Intramuscular or Intranasal Administration to Evaluate the Safety and Immunogenicity of the Recombinant Vaccine Against COVID-19 (AVX/COVID-12 “Patria”) Based on an Active Newcastle Disease Viral Vector as a Heterologous Booster in Subjects with Evidence of Previous Immunity to SARS-CoV-2","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nuclear Waste Management Organization","funders":"Institute of Nuclear Energy Research; Instituto Politécnico Nacional","keywords":"Immunogenicity; Booster dose; Medicine; Booster (rocketry); Vaccination; Immune system; Immunology; Virology; Neutralizing antibody; Nasal administration; Herd immunity; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007484406,0.004661816,0.005448339,0.001484882,0.001266078,0.001889489,0.002317231,0.005372683,0.009466012],"category_scores_gemma":[0.005112366,0.002217635,0.00272686,0.0009715428,0.003678095,0.002619621,0.0008401201,0.004939867,0.00244582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001479203,"about_ca_system_score_gemma":0.003894825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006436409,"about_ca_topic_score_gemma":0.0009863793,"domain_scores_codex":[0.9959344,0.001854806,0.0002838078,0.0009610854,0.0003672518,0.0005987505],"domain_scores_gemma":[0.9953477,0.001092515,0.0009110312,0.0007172491,0.0007244042,0.001207168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9147654,0.06771863,0.0003891812,0.0005123506,0.0003990865,0.00002770621,0.00006993116,0.0003538368,0.006683024,0.0002326934,0.0006773393,0.008170767],"study_design_scores_gemma":[0.783681,0.2134352,0.0004281975,0.00001676147,0.0001439712,0.00001344234,0.00001596222,0.0003273159,0.001095667,0.000157762,0.0006675331,0.00001725321],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8217664,0.002205892,0.008298525,0.001109052,0.003201376,0.1552524,0.003155289,0.0005166596,0.004494315],"genre_scores_gemma":[0.7336153,0.001652891,0.0238915,0.002794609,0.002183537,0.2237042,0.002038824,0.0001330952,0.009986067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009466012,"threshold_uncertainty_score":0.03958178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124407700919741,"score_gpt":0.4313383410505466,"score_spread":0.3188975709585725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}