{"id":"W4391772853","doi":"10.1016/j.ejmech.2024.116238","title":"Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy","year":2024,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Fibroblast activation protein, alpha; Quinoline; Cancer imaging; Cancer therapy; Cancer research; Profiling (computer programming); Radiochemistry; Pharmacology; Cancer; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001425439,0.0001499607,0.0003400455,0.0001371641,0.00004898288,0.00001525422,0.00006032127,0.00003976903,0.0001077458],"category_scores_gemma":[0.0006160469,0.0001164342,0.0001019756,0.0001671428,0.0001091696,0.00008982554,0.00001360428,0.000254729,1.852789e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006050467,"about_ca_system_score_gemma":0.0004418469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.260985e-7,"about_ca_topic_score_gemma":1.00669e-7,"domain_scores_codex":[0.9983957,0.00008852223,0.0007525096,0.0001949428,0.0004460314,0.000122288],"domain_scores_gemma":[0.9987009,0.000215095,0.0004574283,0.00008608735,0.0004155925,0.0001249155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001573684,0.00009988426,0.0006777293,0.002819665,0.0002099029,0.00002695027,0.0004077315,0.00006758948,0.9486568,8.672313e-7,0.00008523308,0.04537398],"study_design_scores_gemma":[0.004137728,0.000459416,0.00286239,0.02106815,0.0002215188,0.00009311019,0.0001972352,0.01866781,0.9517275,0.000005809967,0.0004508097,0.0001085363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849385,0.008875229,0.004609659,0.001056082,0.00002021694,0.0003887057,0.00001054566,0.000012246,0.00008883904],"genre_scores_gemma":[0.9948093,0.0001559264,0.004484897,0.00008166524,0.0003689937,0.000009940301,0.00002594954,0.000028725,0.0000345612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04526545,"threshold_uncertainty_score":0.4748051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03737533026759288,"score_gpt":0.3351168804384025,"score_spread":0.2977415501708096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}