{"id":"W4391773582","doi":"10.1101/2024.02.12.24302279","title":"Quantification of [ <sup>11</sup> C]ABP688 binding in human brain using cerebellum as reference region: biological interpretation and limitations","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Montreal Neurological Institute and Hospital; McMaster University","funders":"Canadian Institutes of Health Research; Health Canada; Government of Canada; Fondation Brain Canada; Alzheimer's Association","keywords":"Cerebellum; Binding potential; In vivo; Human brain; Chemistry; Positron emission tomography; Nuclear magnetic resonance; Nuclear medicine; Biology; Neuroscience; Medicine; Physics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008504445,0.000756492,0.0006037856,0.0007612779,0.0004378496,0.001884441,0.001545196,0.001046192,0.001312971],"category_scores_gemma":[0.008666804,0.0006248183,0.0002966241,0.0008407043,0.001359024,0.0008422333,0.0004318962,0.0004169968,0.0006049209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007936659,"about_ca_system_score_gemma":0.0006723868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00865658,"about_ca_topic_score_gemma":0.007675126,"domain_scores_codex":[0.9969642,0.00139325,0.0002659816,0.0006337902,0.0006525775,0.00009018165],"domain_scores_gemma":[0.9955708,0.001888407,0.0006364653,0.00109887,0.0007433982,0.00006198356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002437592,0.00008805768,0.03704893,0.002862124,0.0007255003,0.001301092,0.0008779936,0.007582878,0.8292404,0.004148956,0.003030076,0.1106563],"study_design_scores_gemma":[0.0001334549,0.001658128,0.1870014,0.000727493,0.001494451,0.01030423,0.0009779056,0.05615477,0.7014696,0.006519583,0.03338458,0.0001743988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4970056,0.03297869,0.4546191,0.001375993,0.0003580679,0.0004833675,0.002250311,0.001992303,0.008936434],"genre_scores_gemma":[0.9251022,0.003404882,0.06828699,0.0005057391,0.00004372119,0.0004975017,0.0006139129,0.0003589036,0.001186134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00865658,"threshold_uncertainty_score":0.04497635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3183013356018162,"score_gpt":0.4219552512588185,"score_spread":0.1036539156570023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}