{"id":"W4391774270","doi":"10.1167/iovs.65.2.27","title":"Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines – A Pilot Study","year":2024,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Genentech; Heidelberg Engineering; Rheinische Friedrich-Wilhelms-Universität Bonn; Allergan; Apellis Pharmaceuticals; Alexion Pharmaceuticals; Astellas Pharma; European Commission; NightstaRx","keywords":"Epigenetics; Melanoma; GNAQ; Cancer research; Histone; Chromatin; Biology; Cell biology; Molecular biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402103,0.0003218416,0.0001733928,0.0005105542,0.000245775,0.0002345454,0.0001660874,0.0002539382,0.0006964095],"category_scores_gemma":[0.0002429601,0.00008568884,0.0002388405,0.0003518536,0.0001644924,0.0001071499,0.0002131101,0.0002036991,0.0002925282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367897,"about_ca_system_score_gemma":0.0001451736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009092648,"about_ca_topic_score_gemma":0.001562271,"domain_scores_codex":[0.9998538,0.00002314396,0.00001272129,0.0000458235,0.00004411143,0.00002030758],"domain_scores_gemma":[0.9998634,0.00002474349,0.00003024318,0.00002202281,0.00003824661,0.00002127403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008048918,0.00002209713,0.002336439,0.00002938487,0.00001052941,0.00004407281,0.00002050515,0.00002719993,0.9956469,0.000007931528,0.00001675846,0.001757676],"study_design_scores_gemma":[0.00001552391,0.0006148391,0.1100894,0.00001174268,0.0000736018,0.001447399,0.0001130174,0.001208207,0.8843815,0.00004126439,0.001990815,0.00001271379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884234,0.002087183,0.007403803,0.00003180329,0.00000958184,0.000119486,0.0011339,0.00007661025,0.00071426],"genre_scores_gemma":[0.9745497,0.001336939,0.02028037,0.00006977436,0.00001287114,0.000115084,0.002411382,0.00002664994,0.001197192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009092648,"threshold_uncertainty_score":0.002329767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0543535970532706,"score_gpt":0.3900816567808158,"score_spread":0.3357280597275452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}