{"id":"W4391774270","doi":"10.1167/iovs.65.2.27","title":"Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines – A Pilot Study","year":2024,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Genentech; Heidelberg Engineering; Rheinische Friedrich-Wilhelms-Universität Bonn; Allergan; Apellis Pharmaceuticals; Alexion Pharmaceuticals; Astellas Pharma; European Commission; NightstaRx","keywords":"Epigenetics; Melanoma; GNAQ; Cancer research; Histone; Chromatin; Biology; Cell biology; Molecular biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007675234,0.0002652678,0.0004792394,0.0007915893,0.0002557085,0.00002747258,0.0002099082,0.0001086485,0.00008438413],"category_scores_gemma":[0.0001593132,0.0002323593,0.00004677453,0.001322591,0.002673902,0.0002098983,0.00005855953,0.0003579972,0.00001878385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002117667,"about_ca_system_score_gemma":0.0009685995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004625666,"about_ca_topic_score_gemma":0.00005075374,"domain_scores_codex":[0.997633,0.000234678,0.0005012922,0.0007936304,0.0004395237,0.0003978513],"domain_scores_gemma":[0.9989167,0.0002722704,0.0001356819,0.0002325067,0.0002137755,0.0002290415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001170359,0.001311779,0.3727105,0.00006847183,0.00005202874,0.0008291555,0.0007669724,0.00001409839,0.6234434,0.0006439761,0.00000169007,0.00004100016],"study_design_scores_gemma":[0.002073192,0.01614265,0.6308467,0.0001088406,0.0001745558,0.000276311,0.0004266583,0.001398596,0.3458812,0.002444823,0.000003824197,0.0002225635],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956725,0.001069653,0.00002310273,0.0006184859,0.0001379996,0.00101363,0.00004337426,0.00004851515,0.001372798],"genre_scores_gemma":[0.989023,0.000002457615,0.0105158,0.00004177082,0.00004720863,0.00009646478,0.00006972161,0.00002075127,0.0001828362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2775621,"threshold_uncertainty_score":0.9852104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0543535970532706,"score_gpt":0.3900816567808158,"score_spread":0.3357280597275452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}