{"id":"W4391780402","doi":"10.1101/2024.02.12.579820","title":"The ChAHP chromatin remodelling complex regulates neurodevelopmental disorder risk genes to scale the production of neocortical layers","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Simons Foundation Autism Research Initiative; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa; McKnight Foundation","keywords":"Biology; Neurogenesis; Homeobox; Chromatin; Transcription factor; Epigenetics; Gene; Cell biology; Chromatin remodeling; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009469602,0.0002176378,0.0001371435,0.0003767826,0.0001708762,0.0003684692,0.0001525101,0.0002084303,0.002070283],"category_scores_gemma":[0.0001594856,0.000155232,0.0002055393,0.0001346229,0.0002547841,0.0001244078,0.0004043845,0.0003294038,0.0003613426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279743,"about_ca_system_score_gemma":0.0002056144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00145599,"about_ca_topic_score_gemma":0.002682911,"domain_scores_codex":[0.9998823,0.000006798913,0.000006404877,0.00004606668,0.00003595963,0.00002231809],"domain_scores_gemma":[0.9998658,0.00002285867,0.00004588742,0.00001226532,0.00002074424,0.00003245788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006786497,0.000008095395,0.007362266,0.00002880976,0.00001507267,0.0001191671,0.00002682795,0.0001437093,0.9886245,0.0003295109,0.00017003,0.003104133],"study_design_scores_gemma":[0.00002319654,0.00009561516,0.2996882,0.00002507976,0.00004568412,0.0008428413,0.000167012,0.006173409,0.6834378,0.0005451987,0.008939962,0.00001601007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817012,0.0010747,0.01186087,0.0001451947,0.00004983386,0.00003465906,0.002182309,0.0002473281,0.002703844],"genre_scores_gemma":[0.9934449,0.0002230077,0.003020652,0.00007303048,0.000008298891,0.00001791873,0.0009178626,0.00003964465,0.002254608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002070283,"threshold_uncertainty_score":0.006925762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055173212006635,"score_gpt":0.2145366518254584,"score_spread":0.203984919705392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}