{"id":"W4391784430","doi":"10.3389/frtra.2024.1350546","title":"Immunogenicity and tolerance induction in vascularized composite allotransplantation","year":2024,"lang":"en","type":"article","venue":"Frontiers in Transplantation","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Immunogenicity; Medicine; Immune system; Population; Immunology; Immune tolerance; Antigen; Transplantation; Allotransplantation; Cancer research; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004729651,0.0002433904,0.0003367195,0.0004340734,0.0001461343,0.0004982264,0.0002622678,0.0002888173,0.0005486434],"category_scores_gemma":[0.0003130605,0.00009027024,0.000336361,0.0002607673,0.0002566687,0.0003953352,0.000262676,0.0006729211,0.0002007085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500392,"about_ca_system_score_gemma":0.0001952622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000987454,"about_ca_topic_score_gemma":0.00007963723,"domain_scores_codex":[0.9997686,0.00007394107,0.00001772174,0.00003428997,0.00007266217,0.00003276196],"domain_scores_gemma":[0.9998947,0.00003473477,0.00002650551,0.000007760997,0.00002386023,0.00001247954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005439097,0.000418262,0.001498769,0.003756409,0.00007728537,0.0006680768,0.0002415726,0.001376424,0.7274609,0.00861906,0.001931154,0.2534083],"study_design_scores_gemma":[0.0000908556,0.006116005,0.009855795,0.0009934605,0.000309493,0.005568564,0.0002084992,0.00274269,0.7927962,0.006214974,0.1750449,0.00005858681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4336303,0.4907461,0.04752045,0.0009166048,0.001430196,0.0003012538,0.0002113543,0.0002583204,0.02498538],"genre_scores_gemma":[0.8137781,0.1669551,0.01125938,0.0007104196,0.0006217495,0.0003262,0.0004025901,0.00004742679,0.005899051],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0005486434,"threshold_uncertainty_score":0.002501309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113880049754598,"score_gpt":0.2752662516806451,"score_spread":0.2641274511830992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}