{"id":"W4391784430","doi":"10.3389/frtra.2024.1350546","title":"Immunogenicity and tolerance induction in vascularized composite allotransplantation","year":2024,"lang":"en","type":"article","venue":"Frontiers in Transplantation","topic":"Organ and Tissue Transplantation Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Immunogenicity; Medicine; Immune system; Population; Immunology; Immune tolerance; Antigen; Transplantation; Allotransplantation; Cancer research; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003040424,0.0001466253,0.0002550696,0.0006163368,0.00003937812,0.000049792,0.00004531911,0.0001325064,0.0000291688],"category_scores_gemma":[0.000003520465,0.0001490768,0.00005066006,0.0005655626,0.00006672829,0.0003150176,0.000001997198,0.000355032,0.00001060604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009532431,"about_ca_system_score_gemma":0.00006388424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002229924,"about_ca_topic_score_gemma":0.0001318788,"domain_scores_codex":[0.9987332,0.00009515293,0.000338356,0.000339499,0.0002691027,0.0002246498],"domain_scores_gemma":[0.9997515,0.00004530054,0.00001882289,0.00009333564,0.00002516288,0.00006586495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007072773,0.0003820153,0.6663986,0.008960024,0.0003078096,0.003061983,0.02264575,0.000752283,0.2432322,0.001112132,0.0001597014,0.04591472],"study_design_scores_gemma":[0.005654209,0.0001264239,0.9535533,0.00141118,0.0001897563,0.0004828,0.000295293,0.01221199,0.02520251,0.0004244982,0.0001936943,0.000254384],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606876,0.003640016,0.03367135,0.0004626009,0.0004708048,0.0005773414,0.00003484451,0.00008970868,0.0003657069],"genre_scores_gemma":[0.9833946,0.01054672,0.005448785,0.0000583085,0.00004196151,0.00003649126,0.0003563618,0.00002286515,0.00009391749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2871547,"threshold_uncertainty_score":0.6079175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113880049754598,"score_gpt":0.2752662516806451,"score_spread":0.2641274511830992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}