{"id":"W4391787253","doi":"10.1073/pnas.2303119121","title":"Capillary oxygen regulates demand–supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Government of Canada; Johns Hopkins University","keywords":"Gap junction; Hyperpolarization (physics); Skeletal muscle; Hypoxia (environmental); Chemistry; Biophysics; Microcirculation; Extracellular; Stimulus (psychology); Cell biology; Anatomy; Biology; Internal medicine; Oxygen; Medicine; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009591336,0.0004268841,0.0004011262,0.0002174459,0.0002552725,0.0009478282,0.0008068875,0.001117662,0.001232272],"category_scores_gemma":[0.001096273,0.000260351,0.0003522791,0.0000942093,0.001712785,0.002318853,0.000669272,0.002134471,0.000172404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004055371,"about_ca_system_score_gemma":0.000324737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000270685,"about_ca_topic_score_gemma":0.0002686872,"domain_scores_codex":[0.9997039,0.00006586078,0.00001885357,0.00006835277,0.00005937385,0.00008359006],"domain_scores_gemma":[0.9993586,0.0002563738,0.0001153916,0.00009008068,0.00007645587,0.0001030409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000367128,0.0001244075,0.00153646,0.0004183885,0.0000314955,0.0005879825,0.0002872522,0.001064279,0.9567212,0.01837317,0.000822194,0.01966599],"study_design_scores_gemma":[0.0004499228,0.00495406,0.05187458,0.000616199,0.000419619,0.002738564,0.001848716,0.05787952,0.7563721,0.06145342,0.06113087,0.0002624431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9409974,0.01345551,0.0313487,0.008123927,0.001105875,0.00006600247,0.00008959915,0.000341606,0.004471453],"genre_scores_gemma":[0.9841734,0.007090327,0.005329813,0.001358023,0.0004292031,0.00005745736,0.0000370637,0.00004744396,0.001477205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232272,"threshold_uncertainty_score":0.005072415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03209270822465034,"score_gpt":0.2714901678428975,"score_spread":0.2393974596182472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}