{"id":"W4391790679","doi":"10.2139/ssrn.4722046","title":"Single Cell Transcriptomic Analysis of SGLT2 Expression Supports an Indirect Role for the Cardioprotective Benefits of Empagliflozin in Heart Failure","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Empagliflozin; Transcriptome; Heart failure; Chemistry; Cell biology; Pharmacology; Gene expression; Internal medicine; Medicine; Biochemistry; Biology; Endocrinology; Diabetes mellitus; Gene; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868864,0.0001896977,0.0004550932,0.000206133,0.0001760513,0.0006051654,0.00007208745,0.0003064768,0.001226987],"category_scores_gemma":[0.0002481336,0.000106426,0.0003624211,0.0002514851,0.0002058925,0.0002476245,0.0002092361,0.0005793927,0.0003281895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153815,"about_ca_system_score_gemma":0.0001712125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000590162,"about_ca_topic_score_gemma":0.0009048661,"domain_scores_codex":[0.999884,0.00001001802,0.000007546601,0.00005027434,0.00002661701,0.00002158679],"domain_scores_gemma":[0.9999105,0.00002997163,0.00001696491,0.00001085714,0.00001695039,0.00001480047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006476889,0.00002845935,0.004550765,0.0001032276,0.00004220472,0.00006259496,0.00004816719,0.0001828287,0.9871925,0.0001568033,0.0005677243,0.00641706],"study_design_scores_gemma":[0.000124612,0.0007915983,0.5553856,0.00005584265,0.000262999,0.0004732368,0.0004007797,0.008932227,0.4228973,0.001421398,0.00920797,0.00004644439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767692,0.00191582,0.01015736,0.0007319232,0.0002095901,0.0000221635,0.007802557,0.0002228872,0.002168517],"genre_scores_gemma":[0.9826712,0.00131067,0.005766433,0.0005884516,0.0001135585,0.00004400573,0.006148589,0.00006593831,0.003291239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001226987,"threshold_uncertainty_score":0.004104674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009845373015219844,"score_gpt":0.2450834594070299,"score_spread":0.2352380863918101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}