{"id":"W4391810225","doi":"10.1016/j.devcel.2024.01.023","title":"Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms","year":2024,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Organoid; Trophoblast; Stem cell; Cell biology; Placenta; Cell; Pregnancy; Fetus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005129515,0.0003036287,0.0002329972,0.0003002096,0.0002029388,0.000387016,0.0002160763,0.0003788551,0.001228316],"category_scores_gemma":[0.000251233,0.0001657289,0.0002142211,0.0002137228,0.0002398789,0.0002751214,0.0002882547,0.0004645727,0.0004287125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294262,"about_ca_system_score_gemma":0.0002234609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274795,"about_ca_topic_score_gemma":0.002167493,"domain_scores_codex":[0.9998031,0.00003980277,0.00001723143,0.00004572196,0.00006725835,0.00002687768],"domain_scores_gemma":[0.9997534,0.00009640479,0.0000253324,0.00003795996,0.00005635821,0.00003048778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003383019,0.0000107856,0.0003164966,0.00002874166,0.00000298308,0.00007337005,0.00007326651,0.0002217212,0.9981432,0.0001485726,0.00001906752,0.0009280609],"study_design_scores_gemma":[0.000003147834,0.00005666677,0.002983973,0.000005775954,0.00001180123,0.0001376384,0.0000788622,0.002200487,0.9930044,0.00007940572,0.001434082,0.000003634382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8740796,0.00252844,0.1139728,0.0001251051,0.0000469745,0.0001900279,0.001438416,0.0003299024,0.007288804],"genre_scores_gemma":[0.9608692,0.001179756,0.03233241,0.00004512849,0.000007951822,0.0001482063,0.0008705936,0.00008841056,0.004458421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274795,"threshold_uncertainty_score":0.004109085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01018513219684422,"score_gpt":0.2208071382038937,"score_spread":0.2106220060070495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}