{"id":"W4391812752","doi":"10.7554/elife.87586.2.sa3","title":"Author Response: ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification System","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Tumor microenvironment; Biology; Kinase; Cell type; Cancer research; Phenotype; Cell biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002115088,0.0008353637,0.0009011548,0.000671947,0.001325125,0.001776876,0.0009927464,0.004878111,0.1292878],"category_scores_gemma":[0.01182112,0.0004127536,0.0008981592,0.000412402,0.0007372388,0.0008950475,0.001970045,0.003064004,0.04472895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001070227,"about_ca_system_score_gemma":0.001823033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526112,"about_ca_topic_score_gemma":0.002518767,"domain_scores_codex":[0.9978924,0.0005819125,0.0001783233,0.0005172509,0.0005443938,0.0002857991],"domain_scores_gemma":[0.9951293,0.001914164,0.0003142131,0.0002805238,0.001532484,0.0008293269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003610513,0.00001331185,0.0008352962,0.0003654417,0.00002041856,0.000232477,0.00009844701,0.0001023238,0.00172004,0.00021129,0.98344,0.01259975],"study_design_scores_gemma":[0.0004202912,0.0001502964,0.004414169,0.0003639542,0.00005116666,0.0006070159,0.0007790675,0.0009187852,0.00328263,0.00175579,0.9871705,0.00008625506],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01269467,0.005973324,0.01004825,0.5232132,0.3534788,0.0008400432,0.03653705,0.01196049,0.04525425],"genre_scores_gemma":[0.08239591,0.003937738,0.01049956,0.5380935,0.06541852,0.002089778,0.02595691,0.00458811,0.2670199],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1292878,"threshold_uncertainty_score":0.4325108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01750860115976836,"score_gpt":0.2843797974517849,"score_spread":0.2668711962920165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}